DegronMD

Uniprot ID: O75444

Source protein: Transcription factor Maf

Source gene: MAF

Class: DEG_SCF_FBW7_1

Location: 55:62

E3 ligase: FBXW7

DEGRON score: 0.9777

ASA_SCORE: 82.9

COIL: 0.9435

CONS_SCORE: 0.4482

DSS_SCORE: 0.5189

HELIX: 0.0212

FCONS_SCORE: 0.9765

RIG_SCORE: 0.6021

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V67A	TCGA-AP-A0LM	UCEC	TCGA	LSSTPMST	DEG_SCF_FBW7_1	0.1944
p.V67A	DO43306	UCEC	ICGC	LSSTPMST	DEG_SCF_FBW7_1	0.1944
p.G53D	TCGA-BR-4361	STAD	TCGA	LSSTPMST	DEG_SCF_FBW7_1	0.2778
p.G53D	DO38887	STAD	ICGC	LSSTPMST	DEG_SCF_FBW7_1	0.2778
p.S65N	TCGA-IB-7651	PAAD	TCGA	LSSTPMST	DEG_SCF_FBW7_1	0.25
p.S65N	DO46657	PAAD	ICGC	LSSTPMST	DEG_SCF_FBW7_1	0.25
p.T58P	TCGA-Z2-A8RT	SKCM	TCGA	LSSTPMST	DEG_SCF_FBW7_1	0.7031
p.T58P	DO51301	SKCM	ICGC	LSSTPMST	DEG_SCF_FBW7_1	0.7031
p.P69L	DO222496	COCA	ICGC	LSSTPMST	DEG_SCF_FBW7_1	0.1389
p.A51T	DO234462	ESAD	ICGC	LSSTPMST	DEG_SCF_FBW7_1	0.2222
p.A51T	SIDM00945	Colorectal Carcinoma	GDSC	LSSTPMST	DEG_SCF_FBW7_1	0.2222
p.A51T	ACH-000895	Colon/Colorectal Cancer	CCLE	LSSTPMST	DEG_SCF_FBW7_1	0.2222
p.A51T	CL-34	large_intestine	COSMIC	LSSTPMST	DEG_SCF_FBW7_1	0.2222
p.P68T	DO229015	LICA	ICGC	LSSTPMST	DEG_SCF_FBW7_1	0.1667
p.T58N	DO229035	LICA	ICGC	LSSTPMST	DEG_SCF_FBW7_1	0.7055
p.S70F	DO229072	PRAD	ICGC	LSSTPMST	DEG_SCF_FBW7_1	0.5556
p.P71L	SIDM00608	Plasma Cell Myeloma	GDSC	LSSTPMST	DEG_SCF_FBW7_1	0.0833
p.P71L	ACH-000714	Myeloma	CCLE	LSSTPMST	DEG_SCF_FBW7_1	0.0833
p.S66P	SIDM01519	Head and Neck Carcinoma	GDSC	LSSTPMST	DEG_SCF_FBW7_1	0.2222
p.S66P	ACH-000992	Head and Neck Cancer	CCLE	LSSTPMST	DEG_SCF_FBW7_1	0.2222
p.G53R	ACH-000402	Lymphoma	CCLE	LSSTPMST	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75444	Transcription factor Maf	DEG_SCF_FBW7_1	55:62	LSSTPMST	FBXW7	0.9777	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons