DegronMD - O75486(SUPT3H)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N142D	TCGA-09-2050	OV	TCGA	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.0833
p.N142D	DO31869	OV	ICGC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.0833
p.K26N	TCGA-DD-AAE3	LIHC	TCGA	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.0556
p.K26N	DO52258	LIHC	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.0556
p.D19Y	TCGA-EO-A3AY	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.D19Y	DO43202	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.D156N	TCGA-EO-A3B0	UCEC	TCGA	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation altering degron motif	0.6932
p.D156N	DO219773	UCEC	ICGC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation altering degron motif	0.6932
p.A6G	DO1140	BRCA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1667
p.R144T	DO222461	BTCA	ICGC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.1389
p.R144T	DO222787	BTCA	ICGC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.1389
p.T20A	DO230311	COCA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.2222
p.D156A	DO222798	COCA	ICGC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation altering degron motif	0.7793
p.T7K	DO229028	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1944
p.F9L	DO229022	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.G21R	DO229177	LMS	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1944
p.G16A	DO222843	MELA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.754
p.A12T	DO228138	PBCA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.7139
p.I24L	DO36556	READ	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1111
p.G17R	DO47911	STAD	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.3056
p.S19I	DO229221	THCA	ICGC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.T6A	SIDM00945	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1667
p.T6A	ACH-000895	Colon/Colorectal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1667
p.T6A	CL-34	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1667
p.D156Y	SIDM00255	Neuroblastoma	GDSC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation altering degron motif	0.7325
p.D156Y	NB17	autonomic ganglia	COSMIC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation altering degron motif	0.7325
p.I147V	SIDM01658	Unknown	GDSC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.2222
p.V162L	ACH-001229	Primary	CCLE	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.1667
p.S7C	ACH-002177	Lung Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1944
p.S7C	NCI-H835	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1944
p.D145Y	ACH-002282	Neuroblastoma	CCLE	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.1667
p.D145Y	NB17	autonomic ganglia	COSMIC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.1667
p.A161V	YKG-1	central nervous system	COSMIC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.1944
p.E10K	COLO-800	skin	COSMIC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.2778
p.D25Y	HCT-15	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.0833
p.S142G	Daudi	haematopoietic and lymphoid tissue	COSMIC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.0833
p.R156L	DG-75	haematopoietic and lymphoid tissue	COSMIC	LAMFED	LIG_APCC_ABBA_1	151:156	Mutation altering degron motif	0.8428

Kaplan plot for SUPT3H in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUPT3H

UniProt ID: O75486

Entrez ID: 8464

Protein name: Transcription initiation protein SPT3 homolog (SPT3-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUPT3H in