DegronMD

Uniprot ID: O75486

Source protein: Transcription initiation protein SPT3 homolog

Source gene: SUPT3H

Class: LIG_APCC_ABBA_1

Location: 151:156

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7895

ASA_SCORE: 76.5

COIL: 0.4705

CONS_SCORE: 0.4916

DSS_SCORE: 0.4475

HELIX: 0.481

FCONS_SCORE: 0.9893

RIG_SCORE: 0.806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N142D	TCGA-09-2050	OV	TCGA	LAMFED	LIG_APCC_ABBA_1	0.0833
p.N142D	DO31869	OV	ICGC	LAMFED	LIG_APCC_ABBA_1	0.0833
p.D156N	TCGA-EO-A3B0	UCEC	TCGA	LAMFED	LIG_APCC_ABBA_1	0.6932
p.D156N	DO219773	UCEC	ICGC	LAMFED	LIG_APCC_ABBA_1	0.6932
p.R144T	DO222461	BTCA	ICGC	LAMFED	LIG_APCC_ABBA_1	0.1389
p.R144T	DO222787	BTCA	ICGC	LAMFED	LIG_APCC_ABBA_1	0.1389
p.D156A	DO222798	COCA	ICGC	LAMFED	LIG_APCC_ABBA_1	0.7793
p.D156Y	SIDM00255	Neuroblastoma	GDSC	LAMFED	LIG_APCC_ABBA_1	0.7325
p.D156Y	NB17	autonomic_ganglia	COSMIC	LAMFED	LIG_APCC_ABBA_1	0.7325
p.I147V	SIDM01658	Unknown	GDSC	LAMFED	LIG_APCC_ABBA_1	0.2222
p.V162L	ACH-001229	Primary	CCLE	LAMFED	LIG_APCC_ABBA_1	0.1667
p.D145Y	ACH-002282	Neuroblastoma	CCLE	LAMFED	LIG_APCC_ABBA_1	0.1667
p.D145Y	NB17	autonomic_ganglia	COSMIC	LAMFED	LIG_APCC_ABBA_1	0.1667
p.A161V	YKG-1	central_nervous_system	COSMIC	LAMFED	LIG_APCC_ABBA_1	0.1944
p.S142G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LAMFED	LIG_APCC_ABBA_1	0.0833
p.R156L	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LAMFED	LIG_APCC_ABBA_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75486	Transcription initiation protein SPT3 homolog	LIG_APCC_ABBA_1	151:156	LAMFED	APC,CDC20,FZR1	0.7895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons