DegronMD - O75487(GPC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V484L	TCGA-17-Z030	LUAD	TCGA	DESSGE	DEG_Kelch_Keap1_1	491:496	Mutation rewiring degron network	0.1389
p.V484A	TCGA-A5-A1OF	UCEC	TCGA	DESSGE	DEG_Kelch_Keap1_1	491:496	Mutation rewiring degron network	0.1389
p.V484A	DO42568	UCEC	ICGC	DESSGE	DEG_Kelch_Keap1_1	491:496	Mutation rewiring degron network	0.1389
p.D483N	TCGA-AP-A1DV	UCEC	TCGA	DESSGE	DEG_Kelch_Keap1_1	491:496	Mutation rewiring degron network	0.1111
p.D483N	DO43186	UCEC	ICGC	DESSGE	DEG_Kelch_Keap1_1	491:496	Mutation rewiring degron network	0.1111
p.E496K	TCGA-BS-A0UV	UCEC	TCGA	DESSGE	DEG_Kelch_Keap1_1	491:496	Mutation altering degron motif	0.7022
p.E496K	DO42793	UCEC	ICGC	DESSGE	DEG_Kelch_Keap1_1	491:496	Mutation altering degron motif	0.7022
p.D491N	TCGA-DS-A1OB	CESC	TCGA	DESSGE	DEG_Kelch_Keap1_1	491:496	Mutation altering degron motif	0.5821
p.D491N	DO6323	CESC	ICGC	DESSGE	DEG_Kelch_Keap1_1	491:496	Mutation altering degron motif	0.5821
p.D483E	DO228974	LICA	ICGC	DESSGE	DEG_Kelch_Keap1_1	491:496	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons