DegronMD

Uniprot ID: O75487

Source protein: Glypican-4

Source gene: GPC4

Class: DEG_Kelch_Keap1_1

Location: 491:496

E3 ligase: KEAP1

DEGRON score: 0.7244

ASA_SCORE: 83.7

COIL: 0.9158

CONS_SCORE: 0.5459

DSS_SCORE: 0.4407

HELIX: 0.0402

FCONS_SCORE: 1.046

RIG_SCORE: 0.6288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V484L	TCGA-17-Z030	LUAD	TCGA	DESSGE	DEG_Kelch_Keap1_1	0.1389
p.V484A	TCGA-A5-A1OF	UCEC	TCGA	DESSGE	DEG_Kelch_Keap1_1	0.1389
p.V484A	DO42568	UCEC	ICGC	DESSGE	DEG_Kelch_Keap1_1	0.1389
p.D483N	TCGA-AP-A1DV	UCEC	TCGA	DESSGE	DEG_Kelch_Keap1_1	0.1111
p.D483N	DO43186	UCEC	ICGC	DESSGE	DEG_Kelch_Keap1_1	0.1111
p.E496K	TCGA-BS-A0UV	UCEC	TCGA	DESSGE	DEG_Kelch_Keap1_1	0.7022
p.E496K	DO42793	UCEC	ICGC	DESSGE	DEG_Kelch_Keap1_1	0.7022
p.D491N	TCGA-DS-A1OB	CESC	TCGA	DESSGE	DEG_Kelch_Keap1_1	0.5821
p.D491N	DO6323	CESC	ICGC	DESSGE	DEG_Kelch_Keap1_1	0.5821
p.D483E	DO228974	LICA	ICGC	DESSGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75487	Glypican-4	DEG_Kelch_Keap1_1	491:496	DESSGE	KEAP1	0.7244	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons