DegronMD - O75530(EED)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K66E	TCGA-2W-A8YY	CESC	TCGA	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation substituting flanking lysine	0.25
p.K66E	DO223732	CESC	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation substituting flanking lysine	0.25
p.T48A	TCGA-91-6835	LUAD	TCGA	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.1944
p.T48A	DO233732	GACA	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.1944
p.T48A	DO26082	LUAD	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.1944
p.P63H	TCGA-D3-A1Q3	SKCM	TCGA	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.2222
p.P63H	DO47509	SKCM	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.2222
p.P53H	TCGA-D3-A2JD	SKCM	TCGA	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation altering degron motif	0.7694
p.P53H	DO37543	SKCM	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation altering degron motif	0.7694
p.P56H	TCGA-DA-A1I1	SKCM	TCGA	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation altering degron motif	0.7694
p.P56H	DO37966	SKCM	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation altering degron motif	0.7694
p.D54A	TCGA-EO-A22R	UCEC	TCGA	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation altering degron motif	0.6682
p.D54A	DO42713	UCEC	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation altering degron motif	0.6682
p.R52H	TCGA-F7-A61V	HNSC	TCGA	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.3056
p.R52H	DO44437	HNSC	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.3056
p.N58K	TCGA-L5-A8NS	ESCA	TCGA	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation altering degron motif	0.5806
p.R52C	TCGA-WS-AB45	COAD	TCGA	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.3056
p.R52C	DO51734	COAD	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.3056
p.R52C	DO229051	LICA	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.3056
p.R52C	DO51094	PRAD	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.3056
p.S67I	DO228976	LICA	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.1111
p.R52L	DO229029	LICA	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.3056
p.R52L	DO229025	LICA	ICGC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.3056
p.A43V	SNU-1040	large intestine	COSMIC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation blocking phosphorylation signal	0.5
p.K65R	SNU-1040	large intestine	COSMIC	PDTPTNT	DEG_SCF_FBW7_1	53:59	Mutation rewiring degron network	0.1667

Kaplan plot for EED in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EED

UniProt ID: O75530

Entrez ID: 8726

Protein name: Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EED in