DegronMD

Uniprot ID: O75530

Source protein: Polycomb protein EED

Source gene: EED

Class: DEG_SCF_FBW7_1

Location: 53:59

E3 ligase: FBXW7

DEGRON score: 0.65

ASA_SCORE: 73.8143

COIL: 0.726

CONS_SCORE: 0.333

DSS_SCORE: 0.7356

HELIX: 0.004

FCONS_SCORE: 1.2912

RIG_SCORE: 0.6352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K66E	TCGA-2W-A8YY	CESC	TCGA	PDTPTNT	DEG_SCF_FBW7_1	0.25
p.K66E	DO223732	CESC	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.25
p.T48A	TCGA-91-6835	LUAD	TCGA	PDTPTNT	DEG_SCF_FBW7_1	0.1944
p.T48A	DO233732	GACA	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.1944
p.T48A	DO26082	LUAD	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.1944
p.P63H	TCGA-D3-A1Q3	SKCM	TCGA	PDTPTNT	DEG_SCF_FBW7_1	0.2222
p.P63H	DO47509	SKCM	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.2222
p.P53H	TCGA-D3-A2JD	SKCM	TCGA	PDTPTNT	DEG_SCF_FBW7_1	0.7694
p.P53H	DO37543	SKCM	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.7694
p.P56H	TCGA-DA-A1I1	SKCM	TCGA	PDTPTNT	DEG_SCF_FBW7_1	0.7694
p.P56H	DO37966	SKCM	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.7694
p.D54A	TCGA-EO-A22R	UCEC	TCGA	PDTPTNT	DEG_SCF_FBW7_1	0.6682
p.D54A	DO42713	UCEC	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.6682
p.R52H	TCGA-F7-A61V	HNSC	TCGA	PDTPTNT	DEG_SCF_FBW7_1	0.3056
p.R52H	DO44437	HNSC	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.3056
p.N58K	TCGA-L5-A8NS	ESCA	TCGA	PDTPTNT	DEG_SCF_FBW7_1	0.5806
p.R52C	TCGA-WS-AB45	COAD	TCGA	PDTPTNT	DEG_SCF_FBW7_1	0.3056
p.R52C	DO51734	COAD	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.3056
p.R52C	DO229051	LICA	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.3056
p.R52C	DO51094	PRAD	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.3056
p.S67I	DO228976	LICA	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.1111
p.R52L	DO229029	LICA	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.3056
p.R52L	DO229025	LICA	ICGC	PDTPTNT	DEG_SCF_FBW7_1	0.3056
p.A43V	SNU-1040	large_intestine	COSMIC	PDTPTNT	DEG_SCF_FBW7_1	0.5
p.K65R	SNU-1040	large_intestine	COSMIC	PDTPTNT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75530	Polycomb protein EED	DEG_SCF_FBW7_1	53:59	PDTPTNT	FBXW7	0.65	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons