DegronMD - O75541(ZNF821)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R167C	TCGA-63-A5MM	LUSC	TCGA	LLIHSE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.E174K	TCGA-B5-A1MX	UCEC	TCGA	LLIHSE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.7022
p.G178A	DO10324	COAD	ICGC	LLIHSE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.N161S	DO36556	READ	ICGC	LLIHSE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1111
p.S174F	DO37786	SKCM	ICGC	LLIHSE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.7982
p.G178E	DO38238	STAD	ICGC	LLIHSE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.R167H	SIDM00228	Thyroid Gland Carcinoma	GDSC	LLIHSE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.R167H	ACH-000897	Thyroid Cancer	CCLE	LLIHSE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.A182T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LLIHSE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons