DegronMD

Uniprot ID: O75541

Source protein: Zinc finger protein 821

Source gene: ZNF821

Class: LIG_APCC_ABBA_1

Location: 169:174

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.671

ASA_SCORE: 65.95

COIL: 0.6352

CONS_SCORE: 0.9896

DSS_SCORE: 0.2826

HELIX: 0.0505

FCONS_SCORE: 1.022

RIG_SCORE: 0.7847

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R167C	TCGA-63-A5MM	LUSC	TCGA	LLIHSE	LIG_APCC_ABBA_1	0.2778
p.E174K	TCGA-B5-A1MX	UCEC	TCGA	LLIHSE	LIG_APCC_ABBA_1	0.7022
p.G178A	DO10324	COAD	ICGC	LLIHSE	LIG_APCC_ABBA_1	0.2222
p.N161S	DO36556	READ	ICGC	LLIHSE	LIG_APCC_ABBA_1	0.1111
p.S174F	DO37786	SKCM	ICGC	LLIHSE	LIG_APCC_ABBA_1	0.7982
p.G178E	DO38238	STAD	ICGC	LLIHSE	LIG_APCC_ABBA_1	0.2222
p.R167H	SIDM00228	Thyroid Gland Carcinoma	GDSC	LLIHSE	LIG_APCC_ABBA_1	0.2778
p.R167H	ACH-000897	Thyroid Cancer	CCLE	LLIHSE	LIG_APCC_ABBA_1	0.2778
p.A182T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LLIHSE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75541	Zinc finger protein 821	LIG_APCC_ABBA_1	169:174	LLIHSE	APC,CDC20,FZR1	0.671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons