DegronMD - O75628(REM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A268T	DO227668	COCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.6028
p.R267H	DO234195	ESAD	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.R267H	SIDM00373	Endometrial Carcinoma	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.R267H	SIDM00422	Hodgkin's Lymphoma	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.R267H	SIDM00380	Acute Myeloid Leukemia	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.T276R	DO223065	ESCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.6765
p.R269C	DO233270	GACA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.8301
p.R269C	DO222599	MELA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.8301
p.R274H	DO12070	GBM	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7133
p.A265T	DO229275	THCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.25
p.A280T	DO229213	THCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2222
p.R270C	DO229232	THCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.719
p.A284T	DO229245	THCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.R274C	SIDM02039	Colorectal Carcinoma	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.719
p.R274C	SIDM00053	Pancreatic Carcinoma	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.719
p.R274C	ACH-000563	Lung Cancer	CCLE	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.719
p.R274C	ACH-002164	Pancreatic Cancer	CCLE	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.719
p.R274C	MZ1-PC	pancreas	COSMIC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.719
p.R270H	SIDM00151	Ovarian Carcinoma	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7133
p.R270H	ACH-000966	Ovarian Cancer	CCLE	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7133
p.P261L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.P261L	ACH-000251	Lung Cancer	CCLE	ARRFLARLT	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389

Kaplan plot for REM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

REM1

UniProt ID: O75628

Entrez ID: 28954

Protein name: GTP-binding protein REM 1 (GTPase-regulating endothelial cell sprouting) (Rad and Gem-like GTP-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for REM1 in