DegronMD

Uniprot ID: O75628

Source protein: GTP-binding protein REM 1

Source gene: REM1

Class: DEG_APCC_DBOX_1

Location: 268:276

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7594

ASA_SCORE: 90.5556

COIL: 0.1488

CONS_SCORE: 0.4716

DSS_SCORE: 0.4909

HELIX: 0.8493

FCONS_SCORE: 1.2237

RIG_SCORE: 0.7979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A268T	DO227668	COCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	0.6028
p.R267H	DO234195	ESAD	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	0.3056
p.R267H	SIDM00373	Endometrial Carcinoma	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	0.3056
p.R267H	SIDM00422	Hodgkin's Lymphoma	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	0.3056
p.R267H	SIDM00380	Acute Myeloid Leukemia	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	0.3056
p.T276R	DO223065	ESCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	0.6765
p.R269C	DO233270	GACA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	0.8301
p.R269C	DO222599	MELA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	0.8301
p.R274H	DO12070	GBM	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	0.7133
p.A265T	DO229275	THCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	0.25
p.A280T	DO229213	THCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	0.2222
p.R270C	DO229232	THCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	0.719
p.A284T	DO229245	THCA	ICGC	ARRFLARLT	DEG_APCC_DBOX_1	0.1111
p.R274C	SIDM02039	Colorectal Carcinoma	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	0.719
p.R274C	SIDM00053	Pancreatic Carcinoma	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	0.719
p.R274C	ACH-000563	Lung Cancer	CCLE	ARRFLARLT	DEG_APCC_DBOX_1	0.719
p.R274C	ACH-002164	Pancreatic Cancer	CCLE	ARRFLARLT	DEG_APCC_DBOX_1	0.719
p.R274C	MZ1-PC	pancreas	COSMIC	ARRFLARLT	DEG_APCC_DBOX_1	0.719
p.R270H	SIDM00151	Ovarian Carcinoma	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	0.7133
p.R270H	ACH-000966	Ovarian Cancer	CCLE	ARRFLARLT	DEG_APCC_DBOX_1	0.7133
p.P261L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ARRFLARLT	DEG_APCC_DBOX_1	0.1389
p.P261L	ACH-000251	Lung Cancer	CCLE	ARRFLARLT	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75628	GTP-binding protein REM 1	DEG_APCC_DBOX_1	268:276	ARRFLARLT	APC,CDC20,FZR1	0.7594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons