DegronMD - O75688(PPM1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S376R	TCGA-85-6798	LUSC	TCGA	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.75
p.S376R	DO27295	LUSC	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.75
p.D377N	TCGA-90-7769	LUSC	TCGA	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.D377N	DO26822	LUSC	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.A365T	TCGA-AP-A051	UCEC	TCGA	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.A365T	DO42673	UCEC	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.R360C	TCGA-B5-A3FC	UCEC	TCGA	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0556
p.R360C	DO233641	GACA	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0556
p.R360C	DO41871	UCEC	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0556
p.R360C	SIDM00487	Colorectal Carcinoma	GDSC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0556
p.R360H	TCGA-C8-A12O	BRCA	TCGA	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0556
p.R360H	DO4677	BRCA	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0556
p.S368N	TCGA-W3-A828	SKCM	TCGA	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.S368N	DO51273	SKCM	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.L383V	DO474	BLCA	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1111
p.L383V	DO49065	HNSC	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1111
p.V362F	DO228976	LICA	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1111
p.E375Q	DO35406	PACA	ICGC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.6744
p.S368G	SIDM01617	Endometrial Carcinoma	GDSC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.S368G	ACH-000994	Endometrial/Uterine Cancer	CCLE	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.2778
p.S376G	SIDM00160	Biliary Tract Carcinoma	GDSC	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.75
p.S376G	ACH-000377	Bile Duct Cancer	CCLE	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.75
p.E384D	ACH-001991	Primary	CCLE	LNPHRE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0833

Kaplan plot for PPM1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPM1B

UniProt ID: O75688

Entrez ID: 5495

Protein name: Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPM1B in