DegronMD

Uniprot ID: O75688

Source protein: Protein phosphatase 1B

Source gene: PPM1B

Class: LIG_APCC_ABBA_1

Location: 370:375

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9974

ASA_SCORE: 98.6667

COIL: 0.7422

CONS_SCORE: 0.3409

DSS_SCORE: 0.5474

HELIX: 0.2435

FCONS_SCORE: 1.0578

RIG_SCORE: 0.6598

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S376R	TCGA-85-6798	LUSC	TCGA	LNPHRE	LIG_APCC_ABBA_1	0.75
p.S376R	DO27295	LUSC	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.75
p.S376G	SIDM00160	Biliary Tract Carcinoma	GDSC	LNPHRE	LIG_APCC_ABBA_1	0.75
p.S376G	ACH-000377	Bile Duct Cancer	CCLE	LNPHRE	LIG_APCC_ABBA_1	0.75
p.E375Q	DO35406	PACA	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.6744
p.D377N	TCGA-90-7769	LUSC	TCGA	LNPHRE	LIG_APCC_ABBA_1	0.2778
p.D377N	DO26822	LUSC	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.2778
p.S368N	TCGA-W3-A828	SKCM	TCGA	LNPHRE	LIG_APCC_ABBA_1	0.2778
p.S368N	DO51273	SKCM	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.2778
p.S368G	SIDM01617	Endometrial Carcinoma	GDSC	LNPHRE	LIG_APCC_ABBA_1	0.2778
p.S368G	ACH-000994	Endometrial/Uterine Cancer	CCLE	LNPHRE	LIG_APCC_ABBA_1	0.2778
p.A365T	TCGA-AP-A051	UCEC	TCGA	LNPHRE	LIG_APCC_ABBA_1	0.1944
p.A365T	DO42673	UCEC	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.1944
p.L383V	DO474	BLCA	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.1111
p.L383V	DO49065	HNSC	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.1111
p.V362F	DO228976	LICA	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.1111
p.E384D	ACH-001991	Primary	CCLE	LNPHRE	LIG_APCC_ABBA_1	0.0833
p.R360C	TCGA-B5-A3FC	UCEC	TCGA	LNPHRE	LIG_APCC_ABBA_1	0.0556
p.R360C	DO233641	GACA	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.0556
p.R360C	DO41871	UCEC	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.0556
p.R360C	SIDM00487	Colorectal Carcinoma	GDSC	LNPHRE	LIG_APCC_ABBA_1	0.0556
p.R360H	TCGA-C8-A12O	BRCA	TCGA	LNPHRE	LIG_APCC_ABBA_1	0.0556
p.R360H	DO4677	BRCA	ICGC	LNPHRE	LIG_APCC_ABBA_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75688	Protein phosphatase 1B	LIG_APCC_ABBA_1	370:375	LNPHRE	APC,CDC20,FZR1	0.9974	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons