DegronMD - O75807(PPP1R15A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S660F	TCGA-78-7153	LUAD	TCGA	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.3056
p.S660F	DO26347	LUAD	ICGC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.3056
p.A652T	TCGA-BP-4161	KIRC	TCGA	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.3056
p.A652T	DO17769	KIRC	ICGC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.3056
p.V644I	TCGA-BQ-5890	KIRP	TCGA	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.0833
p.V644I	DO20766	KIRP	ICGC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.0833
p.S659L	TCGA-BT-A3PJ	BLCA	TCGA	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation altering degron motif	0.7667
p.S659L	DO44097	BLCA	ICGC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation altering degron motif	0.7667
p.T646A	TCGA-CJ-5689	KIRC	TCGA	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.1389
p.T646A	DO19853	KIRC	ICGC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.1389
p.T646I	TCGA-CJ-5689	KIRC	TCGA	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.1389
p.T646I	DO19853	KIRC	ICGC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.1389
p.R658H	TCGA-G3-A25W	LIHC	TCGA	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation altering degron motif	0.7133
p.R658H	DO22970	LIHC	ICGC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation altering degron motif	0.7133
p.L669H	DO232861	NACA	ICGC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.0556
p.L649W	DO51107	PRAD	ICGC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.2222
p.S657F	DO229446	SKCA	ICGC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation altering degron motif	0.6871
p.L667M	SIDM00282	Colorectal Carcinoma	GDSC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.1111
p.L667M	ACH-000998	Colon/Colorectal Cancer	CCLE	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.1111
p.L667M	CW-2	large intestine	COSMIC	VATPSRS	DEG_SCF_FBW7_1	653:659	Mutation rewiring degron network	0.1111

Kaplan plot for PPP1R15A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R15A

UniProt ID: O75807

Entrez ID: 23645

Protein name: Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1R15A in