DegronMD

Uniprot ID: O75807

Source protein: Protein phosphatase 1 regulatory subunit 15A

Source gene: PPP1R15A

Class: DEG_SCF_FBW7_1

Location: 653:659

E3 ligase: FBXW7

DEGRON score: 0.9843

ASA_SCORE: 76.0714

COIL: 0.7783

CONS_SCORE: 0.5548

DSS_SCORE: 0.4767

HELIX: 0.1577

FCONS_SCORE: 1.2705

RIG_SCORE: 0.6851

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S660F	TCGA-78-7153	LUAD	TCGA	VATPSRS	DEG_SCF_FBW7_1	0.3056
p.S660F	DO26347	LUAD	ICGC	VATPSRS	DEG_SCF_FBW7_1	0.3056
p.A652T	TCGA-BP-4161	KIRC	TCGA	VATPSRS	DEG_SCF_FBW7_1	0.3056
p.A652T	DO17769	KIRC	ICGC	VATPSRS	DEG_SCF_FBW7_1	0.3056
p.V644I	TCGA-BQ-5890	KIRP	TCGA	VATPSRS	DEG_SCF_FBW7_1	0.0833
p.V644I	DO20766	KIRP	ICGC	VATPSRS	DEG_SCF_FBW7_1	0.0833
p.S659L	TCGA-BT-A3PJ	BLCA	TCGA	VATPSRS	DEG_SCF_FBW7_1	0.7667
p.S659L	DO44097	BLCA	ICGC	VATPSRS	DEG_SCF_FBW7_1	0.7667
p.T646A	TCGA-CJ-5689	KIRC	TCGA	VATPSRS	DEG_SCF_FBW7_1	0.1389
p.T646A	DO19853	KIRC	ICGC	VATPSRS	DEG_SCF_FBW7_1	0.1389
p.T646I	TCGA-CJ-5689	KIRC	TCGA	VATPSRS	DEG_SCF_FBW7_1	0.1389
p.T646I	DO19853	KIRC	ICGC	VATPSRS	DEG_SCF_FBW7_1	0.1389
p.R658H	TCGA-G3-A25W	LIHC	TCGA	VATPSRS	DEG_SCF_FBW7_1	0.7133
p.R658H	DO22970	LIHC	ICGC	VATPSRS	DEG_SCF_FBW7_1	0.7133
p.L669H	DO232861	NACA	ICGC	VATPSRS	DEG_SCF_FBW7_1	0.0556
p.L649W	DO51107	PRAD	ICGC	VATPSRS	DEG_SCF_FBW7_1	0.2222
p.S657F	DO229446	SKCA	ICGC	VATPSRS	DEG_SCF_FBW7_1	0.6871
p.L667M	SIDM00282	Colorectal Carcinoma	GDSC	VATPSRS	DEG_SCF_FBW7_1	0.1111
p.L667M	ACH-000998	Colon/Colorectal Cancer	CCLE	VATPSRS	DEG_SCF_FBW7_1	0.1111
p.L667M	CW-2	large_intestine	COSMIC	VATPSRS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75807	Protein phosphatase 1 regulatory subunit 15A	DEG_SCF_FBW7_1	653:659	VATPSRS	FBXW7	0.9843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons