DegronMD - O75840(KLF7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S140L	TCGA-16-1045	GBM	TCGA	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation altering degron motif	0.6556
p.S140L	TCGA-QK-A8Z8	HNSC	TCGA	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation altering degron motif	0.6556
p.A132T	TCGA-61-1738	OV	TCGA	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation rewiring degron network	0.2222
p.A132T	DO222973	BTCA	ICGC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation rewiring degron network	0.2222
p.A132T	DO30380	OV	ICGC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation rewiring degron network	0.2222
p.A132T	DO36556	READ	ICGC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation rewiring degron network	0.2222
p.L138V	DO50454	ESAD	ICGC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation altering degron motif	0.6765
p.A144S	DO26428	LUSC	ICGC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation rewiring degron network	0.25
p.V148L	DO49085	LUSC	ICGC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation rewiring degron network	0.1389
p.V130L	DO27046	LUSC	ICGC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation rewiring degron network	0.1667
p.G132D	DO52402	UCEC	ICGC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation rewiring degron network	0.2222
p.V130M	DO41235	UCEC	ICGC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation rewiring degron network	0.1667
p.S141F	SIDM00545	Melanoma	GDSC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation altering degron motif	0.7982
p.S141F	ACH-000987	Skin Cancer	CCLE	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation altering degron motif	0.7982
p.S141F	Mewo	skin	COSMIC	LTPPSS	DEG_SCF_FBW7_1	136:141	Mutation altering degron motif	0.7982

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons