DegronMD

Uniprot ID: O75840

Source protein: Krueppel-like factor 7

Source gene: KLF7

Class: DEG_SCF_FBW7_1

Location: 136:141

E3 ligase: FBXW7

DEGRON score: 0.857

ASA_SCORE: 74.7

COIL: 0.9515

CONS_SCORE: 0.7847

DSS_SCORE: 0.4855

HELIX: 0.0172

FCONS_SCORE: 1.4646

RIG_SCORE: 0.6466

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S140L	TCGA-16-1045	GBM	TCGA	LTPPSS	DEG_SCF_FBW7_1	0.6556
p.S140L	TCGA-QK-A8Z8	HNSC	TCGA	LTPPSS	DEG_SCF_FBW7_1	0.6556
p.A132T	TCGA-61-1738	OV	TCGA	LTPPSS	DEG_SCF_FBW7_1	0.2222
p.A132T	DO222973	BTCA	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.2222
p.A132T	DO30380	OV	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.2222
p.A132T	DO36556	READ	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.2222
p.L138V	DO50454	ESAD	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.6765
p.A144S	DO26428	LUSC	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.25
p.V148L	DO49085	LUSC	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.1389
p.V130L	DO27046	LUSC	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.1667
p.G132D	DO52402	UCEC	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.2222
p.V130M	DO41235	UCEC	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.1667
p.S141F	SIDM00545	Melanoma	GDSC	LTPPSS	DEG_SCF_FBW7_1	0.7982
p.S141F	ACH-000987	Skin Cancer	CCLE	LTPPSS	DEG_SCF_FBW7_1	0.7982
p.S141F	Mewo	skin	COSMIC	LTPPSS	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75840	Krueppel-like factor 7	DEG_SCF_FBW7_1	136:141	LTPPSS	FBXW7	0.857	More...
Q2M2I8	AP2-associated protein kinase 1	DEG_SCF_FBW7_1	619:624	LTPPSS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons