DegronMD - Q2M2I8(AAK1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G617V	TCGA-38-4631	LUAD	TCGA	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation rewiring degron network	0.2778
p.G617V	DO24970	LUAD	ICGC	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation rewiring degron network	0.2778
p.K626T	TCGA-A5-A2K5	UCEC	TCGA	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation substituting flanking lysine	0.2778
p.K626T	DO41379	UCEC	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation substituting flanking lysine	0.2778
p.L619V	TCGA-A6-A565	COAD	TCGA	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation altering degron motif	0.5654
p.L619V	DO44090	COAD	ICGC	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation altering degron motif	0.5654
p.R634H	TCGA-B5-A3FC	UCEC	TCGA	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.7133
p.R634H	DO41871	UCEC	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.7133
p.R634H	SIDM00499	Prostate Carcinoma	GDSC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.7133
p.R634H	ACH-000956	Prostate Cancer	CCLE	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.7133
p.R634H	22RV1	prostate	COSMIC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.7133
p.I635V	TCGA-BA-A4IH	HNSC	TCGA	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.5965
p.I635V	DO52029	HNSC	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.5965
p.A455V	TCGA-QQ-A8VG	SARC	TCGA	PPTPQQT	DEG_SCF_FBW7_1	439:445	Mutation rewiring degron network	0.0556
p.A455V	DO220260	SARC	ICGC	PPTPQQT	DEG_SCF_FBW7_1	439:445	Mutation rewiring degron network	0.0556
p.K434R	TCGA-WS-AB45	COAD	TCGA	PPTPQQT	DEG_SCF_FBW7_1	439:445	Mutation substituting flanking lysine	0.3056
p.K434R	DO51734	COAD	ICGC	PPTPQQT	DEG_SCF_FBW7_1	439:445	Mutation substituting flanking lysine	0.3056
p.L636I	DO10843	ESAD	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.7174
p.H632Q	DO223144	ESCA	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.647
p.R634S	DO229028	LICA	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.6316
p.R634S	DO229026	LICA	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.6316
p.P648T	DO229032	LICA	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation rewiring degron network	0.1111
p.Q443K	DO44798	LICA	ICGC	PPTPQQT	DEG_SCF_FBW7_1	439:445	Mutation altering degron motif	0.5833
p.G613R	DO229177	LMS	ICGC	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation rewiring degron network	0.1667
p.P609A	DO232058	ORCA	ICGC	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation rewiring degron network	0.0556
p.L619R	DO36248	PRAD	ICGC	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation altering degron motif	0.8428
p.K434N	SIDM00602	Gastric Carcinoma	GDSC	PPTPQQT	DEG_SCF_FBW7_1	439:445	Mutation substituting flanking lysine	0.3056
p.S624F	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation altering degron motif	0.9093
p.S624F	ACH-002263	Esophageal Cancer	CCLE	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation altering degron motif	0.9093
p.S624F	KYSE-220	oesophagus	COSMIC	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation altering degron motif	0.9093
p.Q435H	SIDM00217	Colorectal Carcinoma	GDSC	PPTPQQT	DEG_SCF_FBW7_1	439:445	Mutation rewiring degron network	0.2222
p.Q435H	ACH-000999	Colon/Colorectal Cancer	CCLE	PPTPQQT	DEG_SCF_FBW7_1	439:445	Mutation rewiring degron network	0.2222
p.Q435H	SNU-1040	large intestine	COSMIC	PPTPQQT	DEG_SCF_FBW7_1	439:445	Mutation rewiring degron network	0.2222
p.R634C	SIDM01619	Endometrial Carcinoma	GDSC	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.719
p.R634C	ACH-000984	Endometrial/Uterine Cancer	CCLE	HRRILSDVT	DEG_APCC_DBOX_1	632:640	Mutation altering degron motif	0.719
p.V611A	ACH-001091	Colon/Colorectal Cancer	CCLE	LTPPSS	DEG_SCF_FBW7_1	619:624	Mutation rewiring degron network	0.1111
p.S447F	ACH-002509	Skin Cancer	CCLE	PPTPQQT	DEG_SCF_FBW7_1	439:445	Mutation rewiring degron network	0.2778

Kaplan plot for AAK1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AAK1

UniProt ID: Q2M2I8

Entrez ID: 22848

Protein name: AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for AAK1 in