DegronMD

Uniprot ID: Q2M2I8

Source protein: AP2-associated protein kinase 1

Source gene: AAK1

Class: DEG_SCF_FBW7_1

Location: 619:624

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 81.8333

COIL: 0.9645

CONS_SCORE: 0.3919

DSS_SCORE: 0.7775

HELIX: 0.0105

FCONS_SCORE: 1.2552

RIG_SCORE: 0.5948

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G617V	TCGA-38-4631	LUAD	TCGA	LTPPSS	DEG_SCF_FBW7_1	0.2778
p.G617V	DO24970	LUAD	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.2778
p.L619V	TCGA-A6-A565	COAD	TCGA	LTPPSS	DEG_SCF_FBW7_1	0.5654
p.L619V	DO44090	COAD	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.5654
p.G613R	DO229177	LMS	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.1667
p.P609A	DO232058	ORCA	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.0556
p.L619R	DO36248	PRAD	ICGC	LTPPSS	DEG_SCF_FBW7_1	0.8428
p.S624F	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LTPPSS	DEG_SCF_FBW7_1	0.9093
p.S624F	ACH-002263	Esophageal Cancer	CCLE	LTPPSS	DEG_SCF_FBW7_1	0.9093
p.S624F	KYSE-220	oesophagus	COSMIC	LTPPSS	DEG_SCF_FBW7_1	0.9093
p.V611A	ACH-001091	Colon/Colorectal Cancer	CCLE	LTPPSS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75840	Krueppel-like factor 7	DEG_SCF_FBW7_1	136:141	LTPPSS	FBXW7	0.857	More...
Q2M2I8	AP2-associated protein kinase 1	DEG_SCF_FBW7_1	619:624	LTPPSS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons