DegronMD

Uniprot ID: Q2M2I8

Source protein: AP2-associated protein kinase 1

Source gene: AAK1

Class: DEG_SCF_FBW7_1

Location: 439:445

E3 ligase: FBXW7

DEGRON score: 0.9496

ASA_SCORE: 94.9857

COIL: 0.9654

CONS_SCORE: 0.2723

DSS_SCORE: 0.9133

HELIX: 0.0164

FCONS_SCORE: 0.8975

RIG_SCORE: 0.5084

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A455V	TCGA-QQ-A8VG	SARC	TCGA	PPTPQQT	DEG_SCF_FBW7_1	0.0556
p.A455V	DO220260	SARC	ICGC	PPTPQQT	DEG_SCF_FBW7_1	0.0556
p.K434R	TCGA-WS-AB45	COAD	TCGA	PPTPQQT	DEG_SCF_FBW7_1	0.3056
p.K434R	DO51734	COAD	ICGC	PPTPQQT	DEG_SCF_FBW7_1	0.3056
p.Q443K	DO44798	LICA	ICGC	PPTPQQT	DEG_SCF_FBW7_1	0.5833
p.K434N	SIDM00602	Gastric Carcinoma	GDSC	PPTPQQT	DEG_SCF_FBW7_1	0.3056
p.Q435H	SIDM00217	Colorectal Carcinoma	GDSC	PPTPQQT	DEG_SCF_FBW7_1	0.2222
p.Q435H	ACH-000999	Colon/Colorectal Cancer	CCLE	PPTPQQT	DEG_SCF_FBW7_1	0.2222
p.Q435H	SNU-1040	large_intestine	COSMIC	PPTPQQT	DEG_SCF_FBW7_1	0.2222
p.S447F	ACH-002509	Skin Cancer	CCLE	PPTPQQT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M2I8	AP2-associated protein kinase 1	DEG_SCF_FBW7_1	439:445	PPTPQQT	FBXW7	0.9496	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons