DegronMD

Uniprot ID: Q2M2I8

Source protein: AP2-associated protein kinase 1

Source gene: AAK1

Class: DEG_APCC_DBOX_1

Location: 632:640

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8757

ASA_SCORE: 85.4333

COIL: 0.787

CONS_SCORE: 0.3211

DSS_SCORE: 0.5404

HELIX: 0.1287

FCONS_SCORE: 0.9379

RIG_SCORE: 0.7285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K626T	TCGA-A5-A2K5	UCEC	TCGA	HRRILSDVT	DEG_APCC_DBOX_1	0.2778
p.K626T	DO41379	UCEC	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	0.2778
p.R634H	TCGA-B5-A3FC	UCEC	TCGA	HRRILSDVT	DEG_APCC_DBOX_1	0.7133
p.R634H	DO41871	UCEC	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	0.7133
p.R634H	SIDM00499	Prostate Carcinoma	GDSC	HRRILSDVT	DEG_APCC_DBOX_1	0.7133
p.R634H	ACH-000956	Prostate Cancer	CCLE	HRRILSDVT	DEG_APCC_DBOX_1	0.7133
p.R634H	22RV1	prostate	COSMIC	HRRILSDVT	DEG_APCC_DBOX_1	0.7133
p.I635V	TCGA-BA-A4IH	HNSC	TCGA	HRRILSDVT	DEG_APCC_DBOX_1	0.5965
p.I635V	DO52029	HNSC	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	0.5965
p.L636I	DO10843	ESAD	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	0.7174
p.H632Q	DO223144	ESCA	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	0.647
p.R634S	DO229028	LICA	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	0.6316
p.R634S	DO229026	LICA	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	0.6316
p.P648T	DO229032	LICA	ICGC	HRRILSDVT	DEG_APCC_DBOX_1	0.1111
p.R634C	SIDM01619	Endometrial Carcinoma	GDSC	HRRILSDVT	DEG_APCC_DBOX_1	0.719
p.R634C	ACH-000984	Endometrial/Uterine Cancer	CCLE	HRRILSDVT	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M2I8	AP2-associated protein kinase 1	DEG_APCC_DBOX_1	632:640	HRRILSDVT	APC,CDC20,FZR1	0.8757	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons