DegronMD - O76024(WFS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y241N	TCGA-63-A5MM	LUSC	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation blocking phosphorylation signal	0.5833
p.Y241N	DO219153	LUSC	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation blocking phosphorylation signal	0.5833
p.R228H	TCGA-AJ-A23O	UCEC	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7133
p.R228H	DO43290	UCEC	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7133
p.R232C	TCGA-AZ-4315	COAD	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.719
p.R232C	TCGA-FI-A2D5	UCEC	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.719
p.R232C	DO8842	COAD	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.719
p.R232C	DO41331	UCEC	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.719
p.E237A	TCGA-BR-4361	STAD	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.25
p.E237A	DO38887	STAD	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.25
p.R227M	TCGA-DZ-6133	KIRP	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.8632
p.R227M	DO20762	KIRP	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.8632
p.R228C	TCGA-IB-7651	PAAD	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.719
p.R228C	DO46657	PAAD	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.719
p.R228C	ACH-000950	Colon/Colorectal Cancer	CCLE	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.719
p.V219M	DO227987	COCA	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.S222F	DO231948	LICA	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.2222
p.K239N	DO228948	LICA	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation substituting flanking lysine	0.3056
p.G217C	DO229027	LICA	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.0833
p.S236R	DO233293	NACA	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation blocking phosphorylation signal	0.7222
p.R232H	SIDM01943	Colorectal Carcinoma	GDSC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7133
p.A243V	SIDM01083	Oral Cavity Carcinoma	GDSC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.0833
p.A243V	SCC-15	upper aerodigestive tract	COSMIC	QRRMLERLV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.0833

Kaplan plot for WFS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WFS1

UniProt ID: O76024

Entrez ID: 7466

Protein name: Wolframin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WFS1 in