DegronMD

Uniprot ID: O76024

Source protein: Wolframin

Source gene: WFS1

Class: DEG_APCC_DBOX_1

Location: 226:234

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8693

ASA_SCORE: 90.6333

COIL: 0.1241

CONS_SCORE: 0.6425

DSS_SCORE: 0.4338

HELIX: 0.872

FCONS_SCORE: 1.0435

RIG_SCORE: 0.7878

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R227M	TCGA-DZ-6133	KIRP	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	0.8632
p.R227M	DO20762	KIRP	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.8632
p.S236R	DO233293	NACA	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.7222
p.R232C	TCGA-AZ-4315	COAD	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	0.719
p.R232C	TCGA-FI-A2D5	UCEC	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	0.719
p.R232C	DO8842	COAD	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.719
p.R232C	DO41331	UCEC	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.719
p.R228C	TCGA-IB-7651	PAAD	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	0.719
p.R228C	DO46657	PAAD	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.719
p.R228C	ACH-000950	Colon/Colorectal Cancer	CCLE	QRRMLERLV	DEG_APCC_DBOX_1	0.719
p.R228H	TCGA-AJ-A23O	UCEC	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	0.7133
p.R228H	DO43290	UCEC	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.7133
p.R232H	SIDM01943	Colorectal Carcinoma	GDSC	QRRMLERLV	DEG_APCC_DBOX_1	0.7133
p.Y241N	TCGA-63-A5MM	LUSC	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	0.5833
p.Y241N	DO219153	LUSC	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.5833
p.K239N	DO228948	LICA	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.3056
p.E237A	TCGA-BR-4361	STAD	TCGA	QRRMLERLV	DEG_APCC_DBOX_1	0.25
p.E237A	DO38887	STAD	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.25
p.S222F	DO231948	LICA	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.2222
p.V219M	DO227987	COCA	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.1389
p.G217C	DO229027	LICA	ICGC	QRRMLERLV	DEG_APCC_DBOX_1	0.0833
p.A243V	SIDM01083	Oral Cavity Carcinoma	GDSC	QRRMLERLV	DEG_APCC_DBOX_1	0.0833
p.A243V	SCC-15	upper_aerodigestive_tract	COSMIC	QRRMLERLV	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76024	Wolframin	DEG_APCC_DBOX_1	226:234	QRRMLERLV	APC,CDC20,FZR1	0.8693	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons