DegronMD - O76074(PDE5A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A193V	DO52432	COCA	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.2778
p.A193V	DO43041	UCEC	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.2778
p.A193V	ACH-001143	Lymphoma	CCLE	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.2778
p.C178Y	DO52021	LUSC	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.1944
p.N184S	DO232761	PBCA	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation altering degron motif	0.7069
p.R180H	DO219784	UCEC	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.25
p.N199S	DO41211	UCEC	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.1111
p.L189F	SIDM00915	Small Cell Lung Carcinoma	GDSC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation altering degron motif	0.587
p.C191S	SIDM01199	Hepatocellular Carcinoma	GDSC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation altering degron motif	0.643
p.C191S	SNU-423	liver	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation altering degron motif	0.643
p.R184H	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation altering degron motif	0.8244
p.R184H	TE-6	oesophagus	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation altering degron motif	0.8244
p.D193Y	SIDM00261	Ewing's Sarcoma	GDSC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.2778
p.D193Y	ES8	bone	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.2778
p.L194F	ACH-000958	Colon/Colorectal Cancer	CCLE	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.25
p.L194F	SW48	large intestine	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.25
p.L184F	SW48	large intestine	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation altering degron motif	0.6981
p.D196V	HCT-116	large intestine	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	183:191	Mutation rewiring degron network	0.1944

Kaplan plot for PDE5A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDE5A

UniProt ID: O76074

Entrez ID: 8654

Protein name: cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDE5A in