DegronMD

Uniprot ID: O76074

Source protein: cGMP-specific 3',5'-cyclic phosphodiesterase

Source gene: PDE5A

Class: DEG_APCC_DBOX_1

Location: 183:191

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6529

ASA_SCORE: 20.3889

COIL: 0.1417

CONS_SCORE: 0.5301

DSS_SCORE: 0.0143

HELIX: 0.0033

FCONS_SCORE: 1.4813

RIG_SCORE: 0.9266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A193V	DO52432	COCA	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	0.2778
p.A193V	DO43041	UCEC	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	0.2778
p.A193V	ACH-001143	Lymphoma	CCLE	DRYSLFLVC	DEG_APCC_DBOX_1	0.2778
p.C178Y	DO52021	LUSC	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	0.1944
p.N184S	DO232761	PBCA	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	0.7069
p.R180H	DO219784	UCEC	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	0.25
p.N199S	DO41211	UCEC	ICGC	DRYSLFLVC	DEG_APCC_DBOX_1	0.1111
p.L189F	SIDM00915	Small Cell Lung Carcinoma	GDSC	DRYSLFLVC	DEG_APCC_DBOX_1	0.587
p.C191S	SIDM01199	Hepatocellular Carcinoma	GDSC	DRYSLFLVC	DEG_APCC_DBOX_1	0.643
p.C191S	SNU-423	liver	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	0.643
p.R184H	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	DRYSLFLVC	DEG_APCC_DBOX_1	0.8244
p.R184H	TE-6	oesophagus	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	0.8244
p.D193Y	SIDM00261	Ewing's Sarcoma	GDSC	DRYSLFLVC	DEG_APCC_DBOX_1	0.2778
p.D193Y	ES8	bone	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	0.2778
p.L194F	ACH-000958	Colon/Colorectal Cancer	CCLE	DRYSLFLVC	DEG_APCC_DBOX_1	0.25
p.L194F	SW48	large_intestine	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	0.25
p.L184F	SW48	large_intestine	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	0.6981
p.D196V	HCT-116	large_intestine	COSMIC	DRYSLFLVC	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	DEG_APCC_DBOX_1	183:191	DRYSLFLVC	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons