DegronMD - O76075(DFFB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R165Q	TCGA-19-1787	GBM	TCGA	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.7329
p.R165Q	DO13522	GBM	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.7329
p.R163W	TCGA-2H-A9GR	ESCA	TCGA	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.3056
p.R163W	DO230342	COCA	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.3056
p.R169M	TCGA-D3-A2JP	SKCM	TCGA	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.7521
p.R169M	DO47407	SKCM	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.7521
p.A182S	DO228976	LICA	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0556
p.G154V	DO231722	LINC	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0556
p.T177M	DO50832	LIRI	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1944
p.P175H	DO34064	PACA	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.25
p.A155T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0833
p.A155T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.0833
p.P163L	SIDM01653	Non-Cancerous	GDSC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.3056
p.A180V	TE-441-T	soft tissue	COSMIC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1111
p.A180V	FADU	upper aerodigestive tract	COSMIC	IRSYLREVS	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1111

Kaplan plot for DFFB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DFFB

UniProt ID: O76075

Entrez ID: 1677

Protein name: DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DFFB in