DegronMD

Uniprot ID: O76075

Source protein: DNA fragmentation factor subunit beta

Source gene: DFFB

Class: DEG_APCC_DBOX_1

Location: 164:172

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.911

ASA_SCORE: 72.8222

COIL: 0.3982

CONS_SCORE: 0.6327

DSS_SCORE: 0.1998

HELIX: 0.5088

FCONS_SCORE: 1.2537

RIG_SCORE: 0.7885

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R165Q	TCGA-19-1787	GBM	TCGA	IRSYLREVS	DEG_APCC_DBOX_1	0.7329
p.R165Q	DO13522	GBM	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	0.7329
p.R163W	TCGA-2H-A9GR	ESCA	TCGA	IRSYLREVS	DEG_APCC_DBOX_1	0.3056
p.R163W	DO230342	COCA	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	0.3056
p.R169M	TCGA-D3-A2JP	SKCM	TCGA	IRSYLREVS	DEG_APCC_DBOX_1	0.7521
p.R169M	DO47407	SKCM	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	0.7521
p.A182S	DO228976	LICA	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	0.0556
p.G154V	DO231722	LINC	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	0.0556
p.T177M	DO50832	LIRI	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	0.1944
p.P175H	DO34064	PACA	ICGC	IRSYLREVS	DEG_APCC_DBOX_1	0.25
p.A155T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	IRSYLREVS	DEG_APCC_DBOX_1	0.0833
p.A155T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	IRSYLREVS	DEG_APCC_DBOX_1	0.0833
p.P163L	SIDM01653	Non-Cancerous	GDSC	IRSYLREVS	DEG_APCC_DBOX_1	0.3056
p.A180V	TE-441-T	soft_tissue	COSMIC	IRSYLREVS	DEG_APCC_DBOX_1	0.1111
p.A180V	FADU	upper_aerodigestive_tract	COSMIC	IRSYLREVS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76075	DNA fragmentation factor subunit beta	DEG_APCC_DBOX_1	164:172	IRSYLREVS	APC,CDC20,FZR1	0.911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons