DegronMD - O76081(RGS20)

FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250, ECO:0000269|PubMed:12379657}.

GO - Biological processes (BP): G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]

GO - Molecular function (MF): GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]

GO - Cellular component (CC): cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A53E	DO231583	LINC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7701
p.A46S	DO37445	SKCM	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7588
p.G52R	DO47869	STAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7568
p.G52R	Hs-445	haematopoietic and lymphoid tissue	COSMIC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7568
p.G45D	DO37474	SKCM	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7198
p.A46T	DO50385	ESAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7139
p.A46T	DO46697	PACA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7139
p.P52T	TCGA-EO-A22X	UCEC	TCGA	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7031
p.P52T	DO43907	UCEC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7031
p.A53V	DO223732	CESC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6936
p.A53V	DO50444	ESAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6936
p.D53N	DO48414	BLCA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6932
p.A50S	TCGA-05-4424	LUAD	TCGA	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6477
p.A50S	TCGA-86-6851	LUAD	TCGA	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6477
p.A50S	DO23798	LUAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6477
p.A50S	DO23672	LUAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6477
p.A50V	TCGA-2W-A8YY	CESC	TCGA	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.5825
p.A50V	DO223732	CESC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.5825
p.N44H	TCGA-EO-A22R	UCEC	TCGA	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.3056
p.N44H	DO42713	UCEC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 37 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS20

UniProt ID: O76081

Entrez ID: 8601

Protein name: Regulator of G-protein signaling 20 (RGS20) (Gz-selective GTPase-activating protein) (G(z)GAP) (Gz-GAP) (Regulator of G-protein signaling Z1) (Regulator of Gz-selective protein signaling 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGS20 in