DegronMD - O76081(RGS20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A50S	TCGA-05-4424	LUAD	TCGA	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6477
p.A50S	TCGA-86-6851	LUAD	TCGA	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6477
p.A50S	DO23798	LUAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6477
p.A50S	DO23672	LUAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6477
p.A50V	TCGA-2W-A8YY	CESC	TCGA	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.5825
p.A50V	DO223732	CESC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.5825
p.N44H	TCGA-EO-A22R	UCEC	TCGA	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.3056
p.N44H	DO42713	UCEC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.3056
p.P52T	TCGA-EO-A22X	UCEC	TCGA	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7031
p.P52T	DO43907	UCEC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7031
p.D53N	DO48414	BLCA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6932
p.Q36H	DO44238	BRCA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.0833
p.A53V	DO223732	CESC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6936
p.A53V	DO50444	ESAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.6936
p.A60T	DO223732	CESC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.1667
p.A60T	DO233697	GACA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.1667
p.R56H	DO51734	COAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.2778
p.A46T	DO50385	ESAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7139
p.A46T	DO46697	PACA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7139
p.P58L	DO233772	GACA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.2222
p.A60S	DO228952	LICA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.1667
p.A60S	DO228978	LICA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.1667
p.S55I	DO229038	LICA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.3056
p.A40S	DO229009	LICA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.1944
p.A53E	DO231583	LINC	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7701
p.F57S	DO27879	ORCA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.25
p.D42E	DO29750	OV	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.25
p.G45D	DO37474	SKCM	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7198
p.A46S	DO37445	SKCM	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7588
p.G52R	DO47869	STAD	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7568
p.G52R	Hs-445	haematopoietic and lymphoid tissue	COSMIC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation altering degron motif	0.7568
p.R35L	DO229275	THCA	ICGC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.0556
p.Q61E	SIDM00583	Pancreatic Carcinoma	GDSC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.1389
p.Q61E	KP-1N	pancreas	COSMIC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.1389
p.R35W	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.0556
p.Q56K	PFSK-1	central nervous system	COSMIC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.2778
p.A39T	CW-2	large intestine	COSMIC	EGDLRAVPDI	DEG_COP1_1	45:54	Mutation rewiring degron network	0.1667

Kaplan plot for RGS20 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS20

UniProt ID: O76081

Entrez ID: 8601

Protein name: Regulator of G-protein signaling 20 (RGS20) (Gz-selective GTPase-activating protein) (G(z)GAP) (Gz-GAP) (Regulator of G-protein signaling Z1) (Regulator of Gz-selective protein signaling 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGS20 in