DegronMD

Uniprot ID: O76081

Source protein: Regulator of G-protein signaling 20

Source gene: RGS20

Class: DEG_COP1_1

Location: 45:54

E3 ligase: COP1

DEGRON score: 0.9337

ASA_SCORE: 71

COIL: 0.7312

CONS_SCORE: 0.5617

DSS_SCORE: 0.4708

HELIX: 0.1395

FCONS_SCORE: 0.9774

RIG_SCORE: 0.7447

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A50S	TCGA-05-4424	LUAD	TCGA	EGDLRAVPDI	DEG_COP1_1	0.6477
p.A50S	TCGA-86-6851	LUAD	TCGA	EGDLRAVPDI	DEG_COP1_1	0.6477
p.A50S	DO23798	LUAD	ICGC	EGDLRAVPDI	DEG_COP1_1	0.6477
p.A50S	DO23672	LUAD	ICGC	EGDLRAVPDI	DEG_COP1_1	0.6477
p.A50V	TCGA-2W-A8YY	CESC	TCGA	EGDLRAVPDI	DEG_COP1_1	0.5825
p.A50V	DO223732	CESC	ICGC	EGDLRAVPDI	DEG_COP1_1	0.5825
p.N44H	TCGA-EO-A22R	UCEC	TCGA	EGDLRAVPDI	DEG_COP1_1	0.3056
p.N44H	DO42713	UCEC	ICGC	EGDLRAVPDI	DEG_COP1_1	0.3056
p.P52T	TCGA-EO-A22X	UCEC	TCGA	EGDLRAVPDI	DEG_COP1_1	0.7031
p.P52T	DO43907	UCEC	ICGC	EGDLRAVPDI	DEG_COP1_1	0.7031
p.D53N	DO48414	BLCA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.6932
p.Q36H	DO44238	BRCA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.0833
p.A53V	DO223732	CESC	ICGC	EGDLRAVPDI	DEG_COP1_1	0.6936
p.A53V	DO50444	ESAD	ICGC	EGDLRAVPDI	DEG_COP1_1	0.6936
p.A60T	DO223732	CESC	ICGC	EGDLRAVPDI	DEG_COP1_1	0.1667
p.A60T	DO233697	GACA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.1667
p.R56H	DO51734	COAD	ICGC	EGDLRAVPDI	DEG_COP1_1	0.2778
p.A46T	DO50385	ESAD	ICGC	EGDLRAVPDI	DEG_COP1_1	0.7139
p.A46T	DO46697	PACA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.7139
p.P58L	DO233772	GACA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.2222
p.A60S	DO228952	LICA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.1667
p.A60S	DO228978	LICA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.1667
p.S55I	DO229038	LICA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.3056
p.A40S	DO229009	LICA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.1944
p.A53E	DO231583	LINC	ICGC	EGDLRAVPDI	DEG_COP1_1	0.7701
p.F57S	DO27879	ORCA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.25
p.D42E	DO29750	OV	ICGC	EGDLRAVPDI	DEG_COP1_1	0.25
p.G45D	DO37474	SKCM	ICGC	EGDLRAVPDI	DEG_COP1_1	0.7198
p.A46S	DO37445	SKCM	ICGC	EGDLRAVPDI	DEG_COP1_1	0.7588
p.G52R	DO47869	STAD	ICGC	EGDLRAVPDI	DEG_COP1_1	0.7568
p.G52R	Hs-445	haematopoietic_and_lymphoid_tissue	COSMIC	EGDLRAVPDI	DEG_COP1_1	0.7568
p.R35L	DO229275	THCA	ICGC	EGDLRAVPDI	DEG_COP1_1	0.0556
p.Q61E	SIDM00583	Pancreatic Carcinoma	GDSC	EGDLRAVPDI	DEG_COP1_1	0.1389
p.Q61E	KP-1N	pancreas	COSMIC	EGDLRAVPDI	DEG_COP1_1	0.1389
p.R35W	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	EGDLRAVPDI	DEG_COP1_1	0.0556
p.Q56K	PFSK-1	central_nervous_system	COSMIC	EGDLRAVPDI	DEG_COP1_1	0.2778
p.A39T	CW-2	large_intestine	COSMIC	EGDLRAVPDI	DEG_COP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EGDLRAVPDI

Degron related mutations and impact score

Drug responses associated with RGS20 mutations

All proteins holding degron of EGDLRAVPDI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76081	Regulator of G-protein signaling 20	DEG_COP1_1	45:54	EGDLRAVPDI	COP1	0.9337	More...