DegronMD - O76094(SRP72)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K564E	TCGA-37-A5EL	LUSC	TCGA	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation substituting flanking lysine	0.3333
p.K564E	DO223718	LUSC	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation substituting flanking lysine	0.3333
p.R581Q	TCGA-AA-3845	COAD	TCGA	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation rewiring degron network	0.1667
p.R581Q	DO10020	COAD	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation rewiring degron network	0.1667
p.A570V	DO8730	COAD	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation altering degron motif	0.6936
p.A575V	DO9876	COAD	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation altering degron motif	0.6936
p.A570D	DO229032	LICA	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation altering degron motif	0.7793
p.I581V	DO23458	LINC	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation rewiring degron network	0.1667
p.P583T	DO37447	SKCM	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation rewiring degron network	0.1111
p.P561S	DO43891	UCEC	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation substituting flanking lysine	0.25
p.D567H	SIDM01300	Colorectal Carcinoma	GDSC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation rewiring degron network	0.3056
p.E582G	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation rewiring degron network	0.1389
p.E582G	ACH-000995	Leukemia	CCLE	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation rewiring degron network	0.1389
p.E582G	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation rewiring degron network	0.1389
p.I581T	PF-382	haematopoietic and lymphoid tissue	COSMIC	PKVTPDPE	DEG_SCF_FBW7_2	568:575	Mutation rewiring degron network	0.1667

Kaplan plot for SRP72 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRP72

UniProt ID: O76094

Entrez ID: 6731

Protein name: Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRP72 in