DegronMD

Uniprot ID: O76094

Source protein: Signal recognition particle subunit SRP72

Source gene: SRP72

Class: DEG_SCF_FBW7_2

Location: 568:575

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 67.8625

COIL: 0.8629

CONS_SCORE: 0.6219

DSS_SCORE: 0.6362

HELIX: 0.1145

FCONS_SCORE: 1.0284

RIG_SCORE: 0.702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K564E	TCGA-37-A5EL	LUSC	TCGA	PKVTPDPE	DEG_SCF_FBW7_2	0.3333
p.K564E	DO223718	LUSC	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	0.3333
p.R581Q	TCGA-AA-3845	COAD	TCGA	PKVTPDPE	DEG_SCF_FBW7_2	0.1667
p.R581Q	DO10020	COAD	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	0.1667
p.A570V	DO8730	COAD	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	0.6936
p.A575V	DO9876	COAD	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	0.6936
p.A570D	DO229032	LICA	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	0.7793
p.I581V	DO23458	LINC	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	0.1667
p.P583T	DO37447	SKCM	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	0.1111
p.P561S	DO43891	UCEC	ICGC	PKVTPDPE	DEG_SCF_FBW7_2	0.25
p.D567H	SIDM01300	Colorectal Carcinoma	GDSC	PKVTPDPE	DEG_SCF_FBW7_2	0.3056
p.E582G	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PKVTPDPE	DEG_SCF_FBW7_2	0.1389
p.E582G	ACH-000995	Leukemia	CCLE	PKVTPDPE	DEG_SCF_FBW7_2	0.1389
p.E582G	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PKVTPDPE	DEG_SCF_FBW7_2	0.1389
p.I581T	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PKVTPDPE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76094	Signal recognition particle subunit SRP72	DEG_SCF_FBW7_2	568:575	PKVTPDPE	FBXW7	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons