DegronMD - O94761(RECQL4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R96L	TCGA-18-3415	LUSC	TCGA	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.7316
p.R96L	DO26427	LUSC	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.7316
p.P94S	TCGA-66-2754	LUSC	TCGA	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6752
p.P94S	DO27612	LUSC	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6752
p.S92P	DO222571	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.5641
p.S92P	DO229010	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.5641
p.S92P	DO229013	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.5641
p.S92P	DO229016	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.5641
p.S92P	DO229003	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.5641
p.S92P	DO229005	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.5641
p.Q91K	DO229029	LICA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.5833
p.P103L	DO232835	NACA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation rewiring degron network	0.1667
p.P103L	SIDM00041	Gastric Carcinoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation rewiring degron network	0.1667
p.P103L	SIDM01111	Ewing's Sarcoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation rewiring degron network	0.1667
p.S92Y	DO232852	NACA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6009
p.S92F	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.S92F	SIDM01118	Small Cell Lung Carcinoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.S92F	SIDM00844	Burkitt's Lymphoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.S92F	SIDM01133	Other Solid Cancers	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.S92F	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.S92F	SIDM01752	Pancreatic Carcinoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.S92F	NCI-H835	lung	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.S92F	Raji	haematopoietic and lymphoid tissue	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.S92F	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.S92F	HCE-4	oesophagus	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.S92F	NCI-H740	lung	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation altering degron motif	0.6871
p.P84S	KYSE-50	oesophagus	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation rewiring degron network	0.1667
p.P84S	HSC-3	upper aerodigestive tract	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	90:97	Mutation rewiring degron network	0.1667

Kaplan plot for RECQL4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RECQL4

UniProt ID: O94761

Entrez ID: 9401

Protein name: ATP-dependent DNA helicase Q4 (EC 3.6.4.12) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RECQL4 in