DegronMD

Uniprot ID: O94761

Source protein: ATP-dependent DNA helicase Q4

Source gene: RECQL4

Class: DEG_SCF_FBW7_1

Location: 90:97

E3 ligase: FBXW7

DEGRON score: 0.9417

ASA_SCORE: 94.1875

COIL: 0.9384

CONS_SCORE: 0.2609

DSS_SCORE: 0.7725

HELIX: 0.0316

FCONS_SCORE: 0.8914

RIG_SCORE: 0.5499

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R96L	TCGA-18-3415	LUSC	TCGA	PQSTPGRS	DEG_SCF_FBW7_1	0.7316
p.R96L	DO26427	LUSC	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.7316
p.P94S	TCGA-66-2754	LUSC	TCGA	PQSTPGRS	DEG_SCF_FBW7_1	0.6752
p.P94S	DO27612	LUSC	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.6752
p.S92P	DO222571	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.5641
p.S92P	DO229010	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.5641
p.S92P	DO229013	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.5641
p.S92P	DO229016	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.5641
p.S92P	DO229003	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.5641
p.S92P	DO229005	COCA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.5641
p.Q91K	DO229029	LICA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.5833
p.P103L	DO232835	NACA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.1667
p.P103L	SIDM00041	Gastric Carcinoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	0.1667
p.P103L	SIDM01111	Ewing's Sarcoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	0.1667
p.S92Y	DO232852	NACA	ICGC	PQSTPGRS	DEG_SCF_FBW7_1	0.6009
p.S92F	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.S92F	SIDM01118	Small Cell Lung Carcinoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.S92F	SIDM00844	Burkitt's Lymphoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.S92F	SIDM01133	Other Solid Cancers	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.S92F	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.S92F	SIDM01752	Pancreatic Carcinoma	GDSC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.S92F	NCI-H835	lung	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.S92F	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.S92F	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.S92F	HCE-4	oesophagus	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.S92F	NCI-H740	lung	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	0.6871
p.P84S	KYSE-50	oesophagus	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	0.1667
p.P84S	HSC-3	upper_aerodigestive_tract	COSMIC	PQSTPGRS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQSTPGRS

Degron related mutations and impact score

Drug responses associated with RECQL4 mutations

All proteins holding degron of PQSTPGRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94761	ATP-dependent DNA helicase Q4	DEG_SCF_FBW7_1	90:97	PQSTPGRS	FBXW7	0.9417	More...