DegronMD - O94763(URI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R435Q	TCGA-AZ-6601	COAD	TCGA	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.7329
p.R435Q	DO8119	COAD	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.7329
p.L438W	TCGA-D6-6516	HNSC	TCGA	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.7015
p.L438W	DO15623	HNSC	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.7015
p.E445K	TCGA-DF-A2KU	UCEC	TCGA	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.25
p.E445K	DO223286	UCEC	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.25
p.E430D	TCGA-F5-6814	READ	TCGA	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2222
p.E430D	DO36556	READ	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2222
p.E441K	DO465	BLCA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.7022
p.R432G	DO224670	BRCA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2778
p.R432G	DO52540	BRCA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2778
p.S440T	DO1712	BRCA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.7116
p.D432H	DO50328	ESAD	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2778
p.R432L	DO228974	LICA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2778
p.E425D	DO23154	LINC	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.0833
p.E425D	DO45085	LINC	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.0833
p.P427S	DO45317	LUAD	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation blocking phosphorylation signal	0.5833
p.R432Q	DO38567	STAD	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2778
p.R432Q	DO43971	UCEC	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2778
p.F450L	DO47933	STAD	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.1111
p.D450G	DO229539	UTCA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.1111
p.E430K	SIDM00614	Hepatocellular Carcinoma	GDSC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2222
p.E430K	JHH-7	liver	COSMIC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2222
p.D450N	SIDM00151	Ovarian Carcinoma	GDSC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.1111
p.D450N	IGROV-1	ovary	COSMIC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.1111
p.E441D	ACH-000341	Neuroblastoma	CCLE	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.6758
p.E441D	ACH-001029	Bone Cancer	CCLE	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.6758
p.E441D	ACH-001034	Bone Cancer	CCLE	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.6758
p.E441D	SK-N-FI	autonomic ganglia	COSMIC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.6758
p.D432N	ACH-000966	Ovarian Cancer	CCLE	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2778
p.D432N	IGROV-1	ovary	COSMIC	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2778
p.K447N	ACH-000996	Endometrial/Uterine Cancer	CCLE	RRGVLRSIS	DEG_APCC_DBOX_1	434:442	Mutation blocking phosphorylation signal	0.6389

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

URI1

UniProt ID: O94763

Entrez ID: 8725

Protein name: Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for URI1 in