DegronMD

Uniprot ID: O94763

Source protein: Unconventional prefoldin RPB5 interactor 1

Source gene: URI1

Class: DEG_APCC_DBOX_1

Location: 434:442

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.844

ASA_SCORE: 87.1333

COIL: 0.5863

CONS_SCORE: 0.3396

DSS_SCORE: 0.3757

HELIX: 0.1071

FCONS_SCORE: 1.0019

RIG_SCORE: 0.7346

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R435Q	TCGA-AZ-6601	COAD	TCGA	RRGVLRSIS	DEG_APCC_DBOX_1	0.7329
p.R435Q	DO8119	COAD	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.7329
p.L438W	TCGA-D6-6516	HNSC	TCGA	RRGVLRSIS	DEG_APCC_DBOX_1	0.7015
p.L438W	DO15623	HNSC	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.7015
p.E445K	TCGA-DF-A2KU	UCEC	TCGA	RRGVLRSIS	DEG_APCC_DBOX_1	0.25
p.E445K	DO223286	UCEC	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.25
p.E430D	TCGA-F5-6814	READ	TCGA	RRGVLRSIS	DEG_APCC_DBOX_1	0.2222
p.E430D	DO36556	READ	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.2222
p.E441K	DO465	BLCA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.7022
p.R432G	DO224670	BRCA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.2778
p.R432G	DO52540	BRCA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.2778
p.S440T	DO1712	BRCA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.7116
p.D432H	DO50328	ESAD	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.2778
p.R432L	DO228974	LICA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.2778
p.E425D	DO23154	LINC	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.0833
p.E425D	DO45085	LINC	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.0833
p.P427S	DO45317	LUAD	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.5833
p.R432Q	DO38567	STAD	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.2778
p.R432Q	DO43971	UCEC	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.2778
p.F450L	DO47933	STAD	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.1111
p.D450G	DO229539	UTCA	ICGC	RRGVLRSIS	DEG_APCC_DBOX_1	0.1111
p.E430K	SIDM00614	Hepatocellular Carcinoma	GDSC	RRGVLRSIS	DEG_APCC_DBOX_1	0.2222
p.E430K	JHH-7	liver	COSMIC	RRGVLRSIS	DEG_APCC_DBOX_1	0.2222
p.D450N	SIDM00151	Ovarian Carcinoma	GDSC	RRGVLRSIS	DEG_APCC_DBOX_1	0.1111
p.D450N	IGROV-1	ovary	COSMIC	RRGVLRSIS	DEG_APCC_DBOX_1	0.1111
p.E441D	ACH-000341	Neuroblastoma	CCLE	RRGVLRSIS	DEG_APCC_DBOX_1	0.6758
p.E441D	ACH-001029	Bone Cancer	CCLE	RRGVLRSIS	DEG_APCC_DBOX_1	0.6758
p.E441D	ACH-001034	Bone Cancer	CCLE	RRGVLRSIS	DEG_APCC_DBOX_1	0.6758
p.E441D	SK-N-FI	autonomic_ganglia	COSMIC	RRGVLRSIS	DEG_APCC_DBOX_1	0.6758
p.D432N	ACH-000966	Ovarian Cancer	CCLE	RRGVLRSIS	DEG_APCC_DBOX_1	0.2778
p.D432N	IGROV-1	ovary	COSMIC	RRGVLRSIS	DEG_APCC_DBOX_1	0.2778
p.K447N	ACH-000996	Endometrial/Uterine Cancer	CCLE	RRGVLRSIS	DEG_APCC_DBOX_1	0.6389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRGVLRSIS

Degron related mutations and impact score

Drug responses associated with URI1 mutations

All proteins holding degron of RRGVLRSIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94763	Unconventional prefoldin RPB5 interactor 1	DEG_APCC_DBOX_1	434:442	RRGVLRSIS	APC,CDC20,FZR1	0.844	More...