DegronMD - O94768(STK17B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G332E	TCGA-06-5416	GBM	TCGA	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1389
p.G332E	TCGA-38-4631	LUAD	TCGA	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1389
p.G332E	DO10880	GBM	ICGC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1389
p.G332E	DO24970	LUAD	ICGC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1389
p.S347I	TCGA-17-Z050	LUAD	TCGA	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.2222
p.S329P	TCGA-AX-A06F	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.0556
p.S329P	DO41752	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.0556
p.N331H	TCGA-CM-6171	COAD	TCGA	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1111
p.N331H	DO8151	COAD	ICGC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1111
p.E341D	TCGA-DS-A1OC	CESC	TCGA	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6758
p.E341D	TCGA-E6-A1LX	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6758
p.E341D	DO6329	CESC	ICGC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6758
p.E341D	DO41020	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6758
p.T333N	DO229019	LICA	ICGC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation blocking phosphorylation signal	0.6111
p.C334R	SIDM00570	Gastric Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1944
p.C334R	SIDM00565	Oral Cavity Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1944
p.C334R	SIDM01460	Glioma	GDSC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1944
p.I343N	SIDM00625	Other Sarcomas	GDSC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.I343N	SIDM00841	Colorectal Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.I343N	SIDM01000	Melanoma	GDSC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.I343N	ACH-000304	Skin Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.I343N	ACH-000449	Sarcoma	CCLE	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.I343N	ACH-000651	Colon/Colorectal Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.I343N	ACH-000842	Colon/Colorectal Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.I343N	ACH-001239	Skin Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.I343N	SW620	large intestine	COSMIC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.I343N	MES-SA	soft tissue	COSMIC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.I343N	WM-115	skin	COSMIC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6169
p.P344R	SIDM00898	Breast Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.3056
p.P344R	ACH-000017	Breast Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.3056
p.P344R	ACH-000248	Breast Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.3056
p.P344R	AU565	breast	COSMIC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.3056
p.G335D	SIDM01617	Endometrial Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.2222
p.G335D	ACH-000994	Endometrial/Uterine Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.2222
p.G335D	ACH-001555	Lung Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.2222

Kaplan plot for STK17B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STK17B

UniProt ID: O94768

Entrez ID: 9262

Protein name: Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STK17B in