DegronMD

Uniprot ID: O94768

Source protein: Serine/threonine-protein kinase 17B

Source gene: STK17B

Class: DEG_APCC_KENBOX_2

Location: 339:343

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9217

ASA_SCORE: 91.68

COIL: 0.5878

CONS_SCORE: 0.5563

DSS_SCORE: 0.6152

HELIX: 0.3906

FCONS_SCORE: 1.1306

RIG_SCORE: 0.6766

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G332E	TCGA-06-5416	GBM	TCGA	DKENI	DEG_APCC_KENBOX_2	0.1389
p.G332E	TCGA-38-4631	LUAD	TCGA	DKENI	DEG_APCC_KENBOX_2	0.1389
p.G332E	DO10880	GBM	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1389
p.G332E	DO24970	LUAD	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1389
p.S347I	TCGA-17-Z050	LUAD	TCGA	DKENI	DEG_APCC_KENBOX_2	0.2222
p.S329P	TCGA-AX-A06F	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	0.0556
p.S329P	DO41752	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	0.0556
p.N331H	TCGA-CM-6171	COAD	TCGA	DKENI	DEG_APCC_KENBOX_2	0.1111
p.N331H	DO8151	COAD	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1111
p.E341D	TCGA-DS-A1OC	CESC	TCGA	DKENI	DEG_APCC_KENBOX_2	0.6758
p.E341D	TCGA-E6-A1LX	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	0.6758
p.E341D	DO6329	CESC	ICGC	DKENI	DEG_APCC_KENBOX_2	0.6758
p.E341D	DO41020	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	0.6758
p.T333N	DO229019	LICA	ICGC	DKENI	DEG_APCC_KENBOX_2	0.6111
p.C334R	SIDM00570	Gastric Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	0.1944
p.C334R	SIDM00565	Oral Cavity Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	0.1944
p.C334R	SIDM01460	Glioma	GDSC	DKENI	DEG_APCC_KENBOX_2	0.1944
p.I343N	SIDM00625	Other Sarcomas	GDSC	DKENI	DEG_APCC_KENBOX_2	0.6169
p.I343N	SIDM00841	Colorectal Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	0.6169
p.I343N	SIDM01000	Melanoma	GDSC	DKENI	DEG_APCC_KENBOX_2	0.6169
p.I343N	ACH-000304	Skin Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.6169
p.I343N	ACH-000449	Sarcoma	CCLE	DKENI	DEG_APCC_KENBOX_2	0.6169
p.I343N	ACH-000651	Colon/Colorectal Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.6169
p.I343N	ACH-000842	Colon/Colorectal Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.6169
p.I343N	ACH-001239	Skin Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.6169
p.I343N	SW620	large_intestine	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.6169
p.I343N	MES-SA	soft_tissue	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.6169
p.I343N	WM-115	skin	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.6169
p.P344R	SIDM00898	Breast Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	0.3056
p.P344R	ACH-000017	Breast Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.3056
p.P344R	ACH-000248	Breast Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.3056
p.P344R	AU565	breast	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.3056
p.G335D	SIDM01617	Endometrial Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	0.2222
p.G335D	ACH-000994	Endometrial/Uterine Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.2222
p.G335D	ACH-001555	Lung Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94768	Serine/threonine-protein kinase 17B	DEG_APCC_KENBOX_2	339:343	DKENI	APC,CDC20,FZR1	0.9217	More...
Q15361	Transcription termination factor 1	DEG_APCC_KENBOX_2	108:112	DKENI	APC,CDC20,FZR1	0.9181	More...
Q8N387	Mucin-15	DEG_APCC_KENBOX_2	58:62	DKENI	APC,CDC20,FZR1	0.8592	More...
Q9BVI0	PHD finger protein 20	DEG_APCC_KENBOX_2	220:224	DKENI	APC,CDC20,FZR1	0.9753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DKENI

Degron related mutations and impact score

Drug responses associated with STK17B mutations

All proteins holding degron of DKENI