DegronMD - Q9BVI0(PHF20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K215R	TCGA-AP-A1DK	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation substituting flanking lysine	0.3056
p.K215R	DO42033	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation substituting flanking lysine	0.3056
p.E230A	TCGA-D8-A27H	BRCA	TCGA	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation rewiring degron network	0.1667
p.E230A	DO1249	BRCA	ICGC	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation rewiring degron network	0.1667
p.G233E	DO234249	ESAD	ICGC	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation rewiring degron network	0.0833
p.K221N	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation altering degron motif	0.6918
p.K221N	ACH-001669	Leukemia	CCLE	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation altering degron motif	0.6918
p.K221N	ACH-002238	Leukemia	CCLE	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation altering degron motif	0.6918
p.K221N	GR-ST	haematopoietic and lymphoid tissue	COSMIC	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation altering degron motif	0.6918
p.S225F	SIDM00596	Endometrial Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation blocking phosphorylation signal	0.75
p.S225F	ACH-001517	Endometrial/Uterine Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation blocking phosphorylation signal	0.75
p.S225F	HEC-1	endometrium	COSMIC	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation blocking phosphorylation signal	0.75
p.E222K	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation altering degron motif	0.7022
p.E222K	ACH-001127	Leukemia	CCLE	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation altering degron motif	0.7022
p.E222K	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation altering degron motif	0.7022
p.S212I	ACH-000760	Brain Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	220:224	Mutation rewiring degron network	0.1111

Kaplan plot for PHF20 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHF20

UniProt ID: Q9BVI0

Entrez ID: 51230

Protein name: PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHF20 in