DegronMD

Uniprot ID: Q9BVI0

Source protein: PHD finger protein 20

Source gene: PHF20

Class: DEG_APCC_KENBOX_2

Location: 220:224

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9753

ASA_SCORE: 99.04

COIL: 0.6694

CONS_SCORE: 0.46

DSS_SCORE: 0.6662

HELIX: 0.3

FCONS_SCORE: 1.0907

RIG_SCORE: 0.671

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S225F	SIDM00596	Endometrial Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	0.75
p.S225F	ACH-001517	Endometrial/Uterine Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.75
p.S225F	HEC-1	endometrium	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.75
p.E222K	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DKENI	DEG_APCC_KENBOX_2	0.7022
p.E222K	ACH-001127	Leukemia	CCLE	DKENI	DEG_APCC_KENBOX_2	0.7022
p.E222K	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.7022
p.K221N	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DKENI	DEG_APCC_KENBOX_2	0.6918
p.K221N	ACH-001669	Leukemia	CCLE	DKENI	DEG_APCC_KENBOX_2	0.6918
p.K221N	ACH-002238	Leukemia	CCLE	DKENI	DEG_APCC_KENBOX_2	0.6918
p.K221N	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.6918
p.K215R	TCGA-AP-A1DK	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	0.3056
p.K215R	DO42033	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	0.3056
p.E230A	TCGA-D8-A27H	BRCA	TCGA	DKENI	DEG_APCC_KENBOX_2	0.1667
p.E230A	DO1249	BRCA	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1667
p.S212I	ACH-000760	Brain Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.1111
p.G233E	DO234249	ESAD	ICGC	DKENI	DEG_APCC_KENBOX_2	0.0833

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N387	Mucin-15	DEG_APCC_KENBOX_2	58:62	DKENI	APC,CDC20,FZR1	0.8592	More...
Q9BVI0	PHD finger protein 20	DEG_APCC_KENBOX_2	220:224	DKENI	APC,CDC20,FZR1	0.9753	More...
O94768	Serine/threonine-protein kinase 17B	DEG_APCC_KENBOX_2	339:343	DKENI	APC,CDC20,FZR1	0.9217	More...
Q15361	Transcription termination factor 1	DEG_APCC_KENBOX_2	108:112	DKENI	APC,CDC20,FZR1	0.9181	More...

Showing 1 to 4 of 4 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons