DegronMD - Q8N387(MUC15)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N166S	TCGA-A6-5665	COAD	TCGA	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.2778
p.N166S	DO9756	COAD	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.2778
p.S191G	TCGA-AA-3864	COAD	TCGA	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0556
p.S191G	DO8490	COAD	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0556
p.P129T	TCGA-AA-3947	COAD	TCGA	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.0833
p.P129T	DO8192	COAD	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.0833
p.I56K	TCGA-AB-2885	LAML	TCGA	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.2778
p.I56K	DO21397	LAML	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.2778
p.D55Y	TCGA-AG-A002	READ	TCGA	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.25
p.E64G	TCGA-AJ-A5DW	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.2778
p.E64G	DO50075	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.2778
p.L139M	TCGA-AN-A046	BRCA	TCGA	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation altering degron motif	0.711
p.L139M	DO1285	BRCA	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation altering degron motif	0.711
p.A63T	TCGA-AP-A056	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.3056
p.A63T	DO43971	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.3056
p.S196I	TCGA-AX-A06F	UCEC	TCGA	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.S196I	DO41752	UCEC	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.K67T	TCGA-B5-A1MR	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1944
p.K67T	TCGA-IG-A97H	ESCA	TCGA	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1944
p.K67T	DO41758	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1944
p.N71K	TCGA-BR-8487	STAD	TCGA	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.0833
p.N71K	DO47867	STAD	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.0833
p.E174K	TCGA-CG-5718	STAD	TCGA	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.0556
p.E174K	DO38340	STAD	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.0556
p.V195I	TCGA-DF-A2KV	UCEC	TCGA	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1667
p.V195I	DO219771	UCEC	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1667
p.S172C	TCGA-DK-A3WW	BLCA	TCGA	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.1111
p.S172C	DO481	BLCA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.1111
p.G50E	TCGA-EB-A431	SKCM	TCGA	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1111
p.G50E	DO37671	SKCM	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1111
p.P209T	TCGA-EE-A183	SKCM	TCGA	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.25
p.P209T	DO37715	SKCM	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.25
p.G216R	TCGA-EJ-8474	PRAD	TCGA	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0556
p.G216R	DO48537	PRAD	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0556
p.A163T	TCGA-FR-A726	SKCM	TCGA	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation altering degron motif	0.7139
p.A163T	DO48665	SKCM	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation altering degron motif	0.7139
p.S172F	TCGA-G2-A2ES	BLCA	TCGA	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.1111
p.S172F	DO785	BLCA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.1111
p.S134F	TCGA-GN-A26C	SKCM	TCGA	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.2222
p.S134F	DO222363	MELA	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.2222
p.S134F	DO222847	MELA	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.2222
p.S134F	DO218849	SKCA	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.2222
p.S134F	DO37782	SKCM	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.2222
p.P160H	TCGA-R5-A7ZI	STAD	TCGA	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation altering degron motif	0.7694
p.P160H	DO222342	STAD	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation altering degron motif	0.7694
p.S142N	TCGA-VQ-A8P2	STAD	TCGA	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation altering degron motif	0.7069
p.S142N	DO51761	STAD	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation altering degron motif	0.7069
p.E70K	TCGA-W3-AA1V	SKCM	TCGA	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1111
p.E70K	DO51276	SKCM	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1111
p.P205L	TCGA-YG-AA3N	SKCM	TCGA	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation altering degron motif	0.7582
p.P205L	DO51298	SKCM	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation altering degron motif	0.7582
p.L171V	DO225263	BRCA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.1389
p.G50V	DO225382	BRCA	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1111
p.I211T	DO228483	BRCA	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	DO229010	COCA	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	DO230659	LAML	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	DO231140	LAML	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00586	Hepatocellular Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00565	Oral Cavity Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00352	Ovarian Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00491	Thyroid Gland Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00602	Gastric Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00463	T-Lymphoblastic Leukemia	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM01144	Gastric Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00533	Pancreatic Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM01196	Hepatocellular Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00351	Oral Cavity Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00299	Other Sarcomas	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00580	Acute Myeloid Leukemia	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM01608	Endometrial Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM01612	Endometrial Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM01335	Kidney Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM01526	Mesothelioma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00169	Head and Neck Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM01770	Gastric Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM00008	Ovarian Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.I211T	SIDM01454	Kidney Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.S48N	DO222404	BTCA	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation blocking phosphorylation signal	0.5
p.S131Y	DO227657	COCA	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.1389
p.T59A	DO233641	GACA	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation altering degron motif	0.7139
p.I153V	DO228210	LICA	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.1111
p.I153V	DO228210	LICA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.1944
p.A154E	DO228952	LICA	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.0833
p.A154E	DO228952	LICA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.2222
p.D55E	DO228974	LICA	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.25
p.P205Q	DO229026	LICA	ICGC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation altering degron motif	0.7035
p.V147M	DO229050	LICA	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.2778
p.Q54K	DO23462	LINC	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.2222
p.P148H	DO228326	MALY	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.25
p.P148H	DO228326	MALY	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.0556
p.N61S	DO228373	MALY	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation altering degron motif	0.7069
p.P169L	DO222662	MELA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.1944
p.P138S	DO218280	ORCA	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation altering degron motif	0.6752
p.E70G	DO35198	PACA	ICGC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1111
p.S142I	DO232224	PBCA	ICGC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation altering degron motif	0.7341
p.V212M	SIDM02012	Colorectal Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1667
p.T130I	SIDM01433	Kidney Carcinoma	GDSC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.1111
p.K59T	ACH-000030	Lung Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation altering degron motif	0.7306
p.K59T	PC-14	lung	COSMIC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation altering degron motif	0.7306
p.N56D	ACH-000990	Endometrial/Uterine Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.2778
p.S65L	ACH-001358	Breast Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.25
p.S65L	MDA-MB-330	breast	COSMIC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.25
p.S72C	ACH-002165	Skin Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.0556
p.S72C	MZ2-MEL	skin	COSMIC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.0556
p.N148K	ACH-002214	Lymphoma	CCLE	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.25
p.N148K	ACH-002214	Lymphoma	CCLE	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.0556
p.N148K	BC-1	haematopoietic and lymphoid tissue	COSMIC	PNATPALS	DEG_SCF_FBW7_1	138:145	Mutation rewiring degron network	0.25
p.N148K	BC-1	haematopoietic and lymphoid tissue	COSMIC	VKTPDNS	DEG_SCF_FBW7_1	158:164	Mutation rewiring degron network	0.0556
p.L55S	ACH-002396	Bone Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.25
p.L55S	Sarc9371	bone	COSMIC	DKENI	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MUC15

UniProt ID: Q8N387

Entrez ID: 143662

Protein name: Mucin-15 (MUC-15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MUC15 in