DegronMD

Uniprot ID: Q8N387

Source protein: Mucin-15

Source gene: MUC15

Class: DEG_SCF_FBW7_1

Location: 138:145

E3 ligase: FBXW7

DEGRON score: 0.962

ASA_SCORE: 78.8375

COIL: 0.9078

CONS_SCORE: 0.4838

DSS_SCORE: 0.3475

HELIX: 0.0343

FCONS_SCORE: 0.858

RIG_SCORE: 0.6893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P129T	TCGA-AA-3947	COAD	TCGA	PNATPALS	DEG_SCF_FBW7_1	0.0833
p.P129T	DO8192	COAD	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.0833
p.L139M	TCGA-AN-A046	BRCA	TCGA	PNATPALS	DEG_SCF_FBW7_1	0.711
p.L139M	DO1285	BRCA	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.711
p.S134F	TCGA-GN-A26C	SKCM	TCGA	PNATPALS	DEG_SCF_FBW7_1	0.2222
p.S134F	DO222363	MELA	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.2222
p.S134F	DO222847	MELA	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.2222
p.S134F	DO218849	SKCA	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.2222
p.S134F	DO37782	SKCM	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.2222
p.S142N	TCGA-VQ-A8P2	STAD	TCGA	PNATPALS	DEG_SCF_FBW7_1	0.7069
p.S142N	DO51761	STAD	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.7069
p.S131Y	DO227657	COCA	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.1389
p.I153V	DO228210	LICA	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.1111
p.A154E	DO228952	LICA	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.0833
p.V147M	DO229050	LICA	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.2778
p.P148H	DO228326	MALY	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.25
p.P138S	DO218280	ORCA	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.6752
p.S142I	DO232224	PBCA	ICGC	PNATPALS	DEG_SCF_FBW7_1	0.7341
p.T130I	SIDM01433	Kidney Carcinoma	GDSC	PNATPALS	DEG_SCF_FBW7_1	0.1111
p.N148K	ACH-002214	Lymphoma	CCLE	PNATPALS	DEG_SCF_FBW7_1	0.25
p.N148K	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PNATPALS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N387	Mucin-15	DEG_SCF_FBW7_1	138:145	PNATPALS	FBXW7	0.962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons