DegronMD

Uniprot ID: Q8N387

Source protein: Mucin-15

Source gene: MUC15

Class: DEG_APCC_KENBOX_2

Location: 58:62

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8592

ASA_SCORE: 115.16

COIL: 0.8492

CONS_SCORE: 0.4931

DSS_SCORE: 0.5647

HELIX: 0.1142

FCONS_SCORE: 0.9824

RIG_SCORE: 0.6884

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I56K	TCGA-AB-2885	LAML	TCGA	DKENI	DEG_APCC_KENBOX_2	0.2778
p.I56K	DO21397	LAML	ICGC	DKENI	DEG_APCC_KENBOX_2	0.2778
p.D55Y	TCGA-AG-A002	READ	TCGA	DKENI	DEG_APCC_KENBOX_2	0.25
p.E64G	TCGA-AJ-A5DW	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	0.2778
p.E64G	DO50075	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	0.2778
p.A63T	TCGA-AP-A056	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	0.3056
p.A63T	DO43971	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	0.3056
p.K67T	TCGA-B5-A1MR	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	0.1944
p.K67T	TCGA-IG-A97H	ESCA	TCGA	DKENI	DEG_APCC_KENBOX_2	0.1944
p.K67T	DO41758	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1944
p.N71K	TCGA-BR-8487	STAD	TCGA	DKENI	DEG_APCC_KENBOX_2	0.0833
p.N71K	DO47867	STAD	ICGC	DKENI	DEG_APCC_KENBOX_2	0.0833
p.G50E	TCGA-EB-A431	SKCM	TCGA	DKENI	DEG_APCC_KENBOX_2	0.1111
p.G50E	DO37671	SKCM	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1111
p.E70K	TCGA-W3-AA1V	SKCM	TCGA	DKENI	DEG_APCC_KENBOX_2	0.1111
p.E70K	DO51276	SKCM	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1111
p.G50V	DO225382	BRCA	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1111
p.S48N	DO222404	BTCA	ICGC	DKENI	DEG_APCC_KENBOX_2	0.5
p.T59A	DO233641	GACA	ICGC	DKENI	DEG_APCC_KENBOX_2	0.7139
p.D55E	DO228974	LICA	ICGC	DKENI	DEG_APCC_KENBOX_2	0.25
p.Q54K	DO23462	LINC	ICGC	DKENI	DEG_APCC_KENBOX_2	0.2222
p.N61S	DO228373	MALY	ICGC	DKENI	DEG_APCC_KENBOX_2	0.7069
p.E70G	DO35198	PACA	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1111
p.K59T	ACH-000030	Lung Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.7306
p.K59T	PC-14	lung	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.7306
p.N56D	ACH-000990	Endometrial/Uterine Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.2778
p.S65L	ACH-001358	Breast Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.25
p.S65L	MDA-MB-330	breast	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.25
p.S72C	ACH-002165	Skin Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.0556
p.S72C	MZ2-MEL	skin	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.0556
p.L55S	ACH-002396	Bone Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.25
p.L55S	Sarc9371	bone	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94768	Serine/threonine-protein kinase 17B	DEG_APCC_KENBOX_2	339:343	DKENI	APC,CDC20,FZR1	0.9217	More...
Q15361	Transcription termination factor 1	DEG_APCC_KENBOX_2	108:112	DKENI	APC,CDC20,FZR1	0.9181	More...
Q8N387	Mucin-15	DEG_APCC_KENBOX_2	58:62	DKENI	APC,CDC20,FZR1	0.8592	More...
Q9BVI0	PHD finger protein 20	DEG_APCC_KENBOX_2	220:224	DKENI	APC,CDC20,FZR1	0.9753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DKENI

Degron related mutations and impact score

Drug responses associated with MUC15 mutations

All proteins holding degron of DKENI