DegronMD

Uniprot ID: Q15361

Source protein: Transcription termination factor 1

Source gene: TTF1

Class: DEG_APCC_KENBOX_2

Location: 108:112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9181

ASA_SCORE: 85.24

COIL: 0.5298

CONS_SCORE: 0.5505

DSS_SCORE: 0.3139

HELIX: 0.386

FCONS_SCORE: 1.2484

RIG_SCORE: 0.8056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D122H	TCGA-17-Z028	LUAD	TCGA	DKENI	DEG_APCC_KENBOX_2	0.0556
p.K117N	TCGA-BS-A0UV	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	0.3056
p.K117N	DO42793	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	0.3056
p.H118R	TCGA-YC-A8S6	BLCA	TCGA	DKENI	DEG_APCC_KENBOX_2	0.1667
p.H118R	DO49806	BLCA	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1667
p.A100V	DO234239	ESAD	ICGC	DKENI	DEG_APCC_KENBOX_2	0.1111
p.T103I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DKENI	DEG_APCC_KENBOX_2	0.1944
p.N114D	SIDM00999	Bladder Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	0.2778
p.N114D	ACH-000973	Bladder Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	0.2778
p.N114D	639-V	urinary_tract	COSMIC	DKENI	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94768	Serine/threonine-protein kinase 17B	DEG_APCC_KENBOX_2	339:343	DKENI	APC,CDC20,FZR1	0.9217	More...
Q15361	Transcription termination factor 1	DEG_APCC_KENBOX_2	108:112	DKENI	APC,CDC20,FZR1	0.9181	More...
Q8N387	Mucin-15	DEG_APCC_KENBOX_2	58:62	DKENI	APC,CDC20,FZR1	0.8592	More...
Q9BVI0	PHD finger protein 20	DEG_APCC_KENBOX_2	220:224	DKENI	APC,CDC20,FZR1	0.9753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons