DegronMD - Q15361(TTF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D122H	TCGA-17-Z028	LUAD	TCGA	DKENI	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.0556
p.S15F	TCGA-17-Z059	LUAD	TCGA	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation blocking phosphorylation signal	0.6111
p.Y867C	TCGA-55-8302	LUAD	TCGA	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.25
p.Y867C	DO45312	LUAD	ICGC	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.25
p.D864N	TCGA-BR-8680	STAD	TCGA	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.6932
p.D864N	DO47769	STAD	ICGC	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.6932
p.K117N	TCGA-BS-A0UV	UCEC	TCGA	DKENI	DEG_APCC_KENBOX_2	108:112	Mutation substituting flanking lysine	0.3056
p.K117N	DO42793	UCEC	ICGC	DKENI	DEG_APCC_KENBOX_2	108:112	Mutation substituting flanking lysine	0.3056
p.H118R	TCGA-YC-A8S6	BLCA	TCGA	DKENI	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1667
p.H118R	DO49806	BLCA	ICGC	DKENI	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1667
p.A100V	DO234239	ESAD	ICGC	DKENI	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1111
p.T852N	DO229015	LICA	ICGC	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1389
p.E873K	SIDM00304	Ovarian Carcinoma	GDSC	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.0833
p.E873K	ACH-002146	Ovarian Cancer	CCLE	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.0833
p.E873K	JHOS-3	ovary	COSMIC	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.0833
p.T103I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DKENI	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1944
p.E35K	SIDM01113	Other Sarcomas	GDSC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation rewiring degron network	0.1111
p.E35K	ACH-000939	Sarcoma	CCLE	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation rewiring degron network	0.1111
p.E35K	SK-UT-1	soft tissue	COSMIC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation rewiring degron network	0.1111
p.T12S	SIDM00178	Melanoma	GDSC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation blocking phosphorylation signal	0.5278
p.T12S	ACH-002386	Skin Cancer	CCLE	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation blocking phosphorylation signal	0.5278
p.N114D	SIDM00999	Bladder Carcinoma	GDSC	DKENI	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.2778
p.N114D	ACH-000973	Bladder Cancer	CCLE	DKENI	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.2778
p.N114D	639-V	urinary tract	COSMIC	DKENI	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.2778
p.K21R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation altering degron motif	0.6126
p.K21R	SIDM00153	T-Lymphoblastic Leukemia	GDSC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation altering degron motif	0.6126
p.K21R	ACH-000964	Leukemia	CCLE	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation altering degron motif	0.6126
p.K21R	ACH-001127	Leukemia	CCLE	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation altering degron motif	0.6126
p.K21R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation altering degron motif	0.6126
p.A854V	SIDM00839	Colorectal Carcinoma	GDSC	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1944
p.A854V	ACH-000950	Colon/Colorectal Cancer	CCLE	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1944
p.A854V	LoVo	large intestine	COSMIC	VFPFRD	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1944
p.E11G	IGROV-1	ovary	COSMIC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	21:27	Mutation rewiring degron network	0.0556

Kaplan plot for TTF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTF1

UniProt ID: Q15361

Entrez ID: 7270

Protein name: Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTF1 in