DegronMD

Uniprot ID: Q15361

Source protein: Transcription termination factor 1

Source gene: TTF1

Class: LIG_APCC_ABBA_1

Location: 859:864

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8875

ASA_SCORE: 66.3

COIL: 0.2975

CONS_SCORE: 0.3853

DSS_SCORE: 0.4189

HELIX: 0.1507

FCONS_SCORE: 1.0237

RIG_SCORE: 0.8474

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y867C	TCGA-55-8302	LUAD	TCGA	VFPFRD	LIG_APCC_ABBA_1	0.25
p.Y867C	DO45312	LUAD	ICGC	VFPFRD	LIG_APCC_ABBA_1	0.25
p.D864N	TCGA-BR-8680	STAD	TCGA	VFPFRD	LIG_APCC_ABBA_1	0.6932
p.D864N	DO47769	STAD	ICGC	VFPFRD	LIG_APCC_ABBA_1	0.6932
p.T852N	DO229015	LICA	ICGC	VFPFRD	LIG_APCC_ABBA_1	0.1389
p.E873K	SIDM00304	Ovarian Carcinoma	GDSC	VFPFRD	LIG_APCC_ABBA_1	0.0833
p.E873K	ACH-002146	Ovarian Cancer	CCLE	VFPFRD	LIG_APCC_ABBA_1	0.0833
p.E873K	JHOS-3	ovary	COSMIC	VFPFRD	LIG_APCC_ABBA_1	0.0833
p.A854V	SIDM00839	Colorectal Carcinoma	GDSC	VFPFRD	LIG_APCC_ABBA_1	0.1944
p.A854V	ACH-000950	Colon/Colorectal Cancer	CCLE	VFPFRD	LIG_APCC_ABBA_1	0.1944
p.A854V	LoVo	large_intestine	COSMIC	VFPFRD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15361	Transcription termination factor 1	LIG_APCC_ABBA_1	859:864	VFPFRD	APC,CDC20,FZR1	0.8875	More...
Q9H9F9	Actin-related protein 5	LIG_APCC_ABBA_1	5:10	VFPFRD	APC,CDC20,FZR1	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons