DegronMD - Q9H9F9(ACTR5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D388H	TCGA-38-4632	LUAD	TCGA	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.25
p.D388H	DO23858	LUAD	ICGC	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.25
p.Q398H	TCGA-DX-A6YV	SARC	TCGA	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.3056
p.Q398H	DO220011	SARC	ICGC	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.3056
p.R12G	DO10840	ESAD	ICGC	VFPFRD	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.2778
p.P391S	DO233884	GACA	ICGC	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation altering degron motif	0.6752
p.P401L	DO52693	MALY	ICGC	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.2222
p.A14V	DO34088	PACA	ICGC	VFPFRD	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.2222
p.E392A	SIDM00773	Non-Cancerous	GDSC	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation altering degron motif	0.659
p.E392A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation altering degron motif	0.659
p.E392A	SIDM00930	Osteosarcoma	GDSC	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation altering degron motif	0.659
p.E392A	SIDM00774	Breast Carcinoma	GDSC	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation altering degron motif	0.659
p.E392A	SIDM01318	Hepatocellular Carcinoma	GDSC	PETPDLE	DEG_SCF_FBW7_2	391:397	Mutation altering degron motif	0.659

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons