DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VFPFRD
Uniprot ID:
Q9H9F9
Source protein:
Actin-related protein 5
Source gene:
ACTR5
Class:
LIG_APCC_ABBA_1
Location:
5:10
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9684
ASA_SCORE:
67.15
COIL:
0.4473
CONS_SCORE:
0.3626
DSS_SCORE:
0.4686
HELIX:
0.029
FCONS_SCORE:
1.1712
RIG_SCORE:
0.7978
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R12G
DO10840
ESAD
ICGC
VFPFRD
LIG_APCC_ABBA_1
0.2778
p.A14V
DO34088
PACA
ICGC
VFPFRD
LIG_APCC_ABBA_1
0.2222
Drug responses associated with ACTR5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VFPFRD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15361
Transcription termination factor 1
LIG_APCC_ABBA_1
859:864
VFPFRD
APC,CDC20,FZR1
0.8875
More...
Q9H9F9
Actin-related protein 5
LIG_APCC_ABBA_1
5:10
VFPFRD
APC,CDC20,FZR1
0.9684
More...