DegronMD

Uniprot ID: Q9H9F9

Source protein: Actin-related protein 5

Source gene: ACTR5

Class: DEG_SCF_FBW7_2

Location: 391:397

E3 ligase: FBXW7

DEGRON score: 0.9914

ASA_SCORE: 83.4571

COIL: 0.7677

CONS_SCORE: 0.4724

DSS_SCORE: 0.6365

HELIX: 0.1911

FCONS_SCORE: 1.1876

RIG_SCORE: 0.6965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D388H	TCGA-38-4632	LUAD	TCGA	PETPDLE	DEG_SCF_FBW7_2	0.25
p.D388H	DO23858	LUAD	ICGC	PETPDLE	DEG_SCF_FBW7_2	0.25
p.Q398H	TCGA-DX-A6YV	SARC	TCGA	PETPDLE	DEG_SCF_FBW7_2	0.3056
p.Q398H	DO220011	SARC	ICGC	PETPDLE	DEG_SCF_FBW7_2	0.3056
p.P391S	DO233884	GACA	ICGC	PETPDLE	DEG_SCF_FBW7_2	0.6752
p.P401L	DO52693	MALY	ICGC	PETPDLE	DEG_SCF_FBW7_2	0.2222
p.E392A	SIDM00773	Non-Cancerous	GDSC	PETPDLE	DEG_SCF_FBW7_2	0.659
p.E392A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PETPDLE	DEG_SCF_FBW7_2	0.659
p.E392A	SIDM00930	Osteosarcoma	GDSC	PETPDLE	DEG_SCF_FBW7_2	0.659
p.E392A	SIDM00774	Breast Carcinoma	GDSC	PETPDLE	DEG_SCF_FBW7_2	0.659
p.E392A	SIDM01318	Hepatocellular Carcinoma	GDSC	PETPDLE	DEG_SCF_FBW7_2	0.659

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H9F9	Actin-related protein 5	DEG_SCF_FBW7_2	391:397	PETPDLE	FBXW7	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons