DegronMD

Uniprot ID: Q15361

Source protein: Transcription termination factor 1

Source gene: TTF1

Class: LIG_APCC_ABBAyCdc20_2

Location: 21:27

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9833

ASA_SCORE: 112.8143

COIL: 0.8134

CONS_SCORE: 0.4432

DSS_SCORE: 0.6765

HELIX: 0.132

FCONS_SCORE: 1.1345

RIG_SCORE: 0.6857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S15F	TCGA-17-Z059	LUAD	TCGA	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.6111
p.E35K	SIDM01113	Other Sarcomas	GDSC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E35K	ACH-000939	Sarcoma	CCLE	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E35K	SK-UT-1	soft_tissue	COSMIC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T12S	SIDM00178	Melanoma	GDSC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.5278
p.T12S	ACH-002386	Skin Cancer	CCLE	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.5278
p.K21R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.6126
p.K21R	SIDM00153	T-Lymphoblastic Leukemia	GDSC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.6126
p.K21R	ACH-000964	Leukemia	CCLE	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.6126
p.K21R	ACH-001127	Leukemia	CCLE	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.6126
p.K21R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.6126
p.E11G	IGROV-1	ovary	COSMIC	KCSIHKE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15361	Transcription termination factor 1	LIG_APCC_ABBAyCdc20_2	21:27	KCSIHKE	APC,CDC20,FZR1	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons