DegronMD

Uniprot ID: Q8N387

Source protein: Mucin-15

Source gene: MUC15

Class: DEG_SCF_FBW7_1

Location: 158:164

E3 ligase: FBXW7

DEGRON score: 0.8368

ASA_SCORE: 93.9

COIL: 0.9204

CONS_SCORE: 0.614

DSS_SCORE: 0.323

HELIX: 0.0259

FCONS_SCORE: 1.1103

RIG_SCORE: 0.7292

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N166S	TCGA-A6-5665	COAD	TCGA	VKTPDNS	DEG_SCF_FBW7_1	0.2778
p.N166S	DO9756	COAD	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.2778
p.E174K	TCGA-CG-5718	STAD	TCGA	VKTPDNS	DEG_SCF_FBW7_1	0.0556
p.E174K	DO38340	STAD	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.0556
p.S172C	TCGA-DK-A3WW	BLCA	TCGA	VKTPDNS	DEG_SCF_FBW7_1	0.1111
p.S172C	DO481	BLCA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.1111
p.A163T	TCGA-FR-A726	SKCM	TCGA	VKTPDNS	DEG_SCF_FBW7_1	0.7139
p.A163T	DO48665	SKCM	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.7139
p.S172F	TCGA-G2-A2ES	BLCA	TCGA	VKTPDNS	DEG_SCF_FBW7_1	0.1111
p.S172F	DO785	BLCA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.1111
p.P160H	TCGA-R5-A7ZI	STAD	TCGA	VKTPDNS	DEG_SCF_FBW7_1	0.7694
p.P160H	DO222342	STAD	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.7694
p.L171V	DO225263	BRCA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.1389
p.I153V	DO228210	LICA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.1944
p.A154E	DO228952	LICA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.2222
p.P148H	DO228326	MALY	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.0556
p.P169L	DO222662	MELA	ICGC	VKTPDNS	DEG_SCF_FBW7_1	0.1944
p.N148K	ACH-002214	Lymphoma	CCLE	VKTPDNS	DEG_SCF_FBW7_1	0.0556
p.N148K	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VKTPDNS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N387	Mucin-15	DEG_SCF_FBW7_1	158:164	VKTPDNS	FBXW7	0.8368	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons